{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:59:15Z","timestamp":1790233155818,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Total E&P Congo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Infectious Diarrhea caused by rotavirus and adenovirus, is a leading cause of death in children in sub\u2010Sahara Africa but there is limited published data on the diverse rotavirus genotypes and adenovirus serotypes circulating in the Republic of Congo. In this study, we investigated the prevalence of severe diarrhea caused by rotavirus A (RVA) and Adenovirus serotype 40 and 41 in Congolese children hospitalized with severe gastroenteritis. Stool samples were collected from 655 Congolese children less than 60 months of age hospitalized with acute gastroenteritis between June 2012 and June 2013. Rotavirus and adenovirus antigens were tested using commercially available ELISA kits and the RVA G\u2010 and P\u2010 genotypes were identified by seminested multiplex RT\u2010PCR. Three hundred and four (46.4%) children were tested positive for RVA. Adenovirus infection was found in 5.5% of the 564 tested children. Rotavirus infection was frequently observed in children between 6\u201312 months (55.9%). The dry season months recorded increased RVA infection while no seasonality of adenovirus infection was demonstrated. The most common RVA genotypes were G1 (57.5%), G2 (6.4%), G1G2 mixture (15.5%), P[8] (58%), P[6] (13.2%), and P[8]P[6] mixture (26%). Additionally, the genotype G12P[6] was significantly associated with increased vomiting. This first study on Congolese children demonstrates a high prevalence and clinical significance of existing rotavirus genotypes. Adenovirus prevalence is similar to that of other Central African countries. This baseline epidemiology and molecular characterization study will contribute significantly to the RVA surveillance after vaccine implementation in the country. <jats:bold><jats:italic>J. Med. Virol. 88:596\u2013605, 2016<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24382","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T12:40:51Z","timestamp":1442493651000},"page":"596-605","source":"Crossref","is-referenced-by-count":41,"title":["Molecular epidemiology and surveillance of circulating rotavirus and adenovirus in Congolese children with gastroenteritis"],"prefix":"10.1002","volume":"88","author":[{"given":"Gontran","family":"Mayindou","sequence":"first","affiliation":[{"name":"Fondation Congolaise pour la Recherche M\u00e9dicale Brazzaville Republic of Congo"},{"name":"Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berge","family":"Ngokana","sequence":"additional","affiliation":[{"name":"Fondation Congolaise pour la Recherche M\u00e9dicale Brazzaville Republic of 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