{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:23:20Z","timestamp":1783441400472,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:00:00Z","timestamp":1451952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>In this meta\u2010analysis, we evaluated the diagnostic role of Epstein\u2010Barr virus deoxyribonucleic acid detection and quantitation in the serum of pediatric and young adult patients with infectious mononucleosis. The primary outcome of this meta\u2010analysis was the sensitivity and specificity of Epstein\u2010Barr virus (EBV) deoxyribonucleic acid (DNA) detection and quantitation using polymerase chain reaction (PCR). A systematic review and meta\u2010analysis was performed by searching for articles that were published through September 24, 2014 in the following databases: Medline, Cochrane, EMBASE, and Google Scholar. The following keywords were used for the search: \u201cEpstein\u2010Barr virus,\u201d \u201cinfectious mononucleosis,\u201d \u201cchildren\/young adults\/infant\/pediatric,\u201d and \u201cpolymerase chain reaction or PCR.\u201d Three were included in this analysis. We found that for detection by PCR, the pooled sensitivity for detecting EBV DNA was 77% (95%CI, 66\u201386%) and the pooled specificity for was 98% (95%CI, 93\u2013100%). Our findings indicate that this PCR\u2010based assay has high specificity and good sensitivity for detecting of EBV DNA, indicating it may useful for identifying patients with infectious mononucleosis. This assay may also be helpful to identify young athletic patients or highly physically active pediatric patients who are at risk for a splenic rupture due to acute infectious mononucleosis. <jats:bold><jats:italic>J. Med. Virol. 88:871\u2013876, 2016<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24402","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T03:27:47Z","timestamp":1444706867000},"page":"871-876","source":"Crossref","is-referenced-by-count":18,"title":["Real\u2010time polymerase chain reaction for diagnosing infectious mononucleosis in pediatric patients: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"88","author":[{"given":"Sha\u2010Yi","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Hematology Children's Hospital of Shanghai Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Shanghai Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Bo","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Shanghai Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Lian","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Shanghai Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Hua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Shanghai Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Shanghai Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/491740"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2015.1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20237"},{"key":"e_1_2_5_5_1","first-page":"799","article-title":"Clinical inquiries. 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