{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T07:04:59Z","timestamp":1743491099400,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences (TUMS)","doi-asserted-by":"crossref","award":["27172"],"award-info":[{"award-number":["27172"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Human Parvovirus B19 (B19V) is a prototype of the<jats:italic>Erythroparvovirus<\/jats:italic>genus in<jats:italic>Parvoviridae<\/jats:italic>family. B19V infections are often associated with fever and rash, and can be mistakenly reported as measles or rubella. Differential diagnosis of B19V illness is necessary for case management and also for public health control activities, particularly in outbreak situations in which measles or rubella is suspected. To investigate the causative role of B19V infection in children with measles\u2010 and rubella\u2010like illness, a total of 583 sera from children with exanthema were tested for presence of B19V by determining anti\u2010B19V IgG and IgM antibodies by ELISA as well as B19V DNA detection by nested PCR. DNA positive samples were assessed further for determination of viral load and sequence analysis by Real\u2010Time PCR and Sanger sequencing method, respectively. Out of 583 patients, 112 (19.21%) patients were positive for B19V\u2010IgM antibody, 110 (18.87%) were positive for B19V\u2010IgG antibody, and 63 (10.81%) were positive for B19V viral DNA. The frequency of B19V\u2010IgG antibodies were increased with age; that is children under 6 year old showed 7.11% seroprevalence for B19V\u2010IgG as compared to 18.39% and 28.91% for age groups 6 to &gt;11 and 11\u201314 years old, respectively. Phylogenetic analysis of the NS1\u2010VPu1 overlapping region revealed that all sequenced B19V\u2010DNA belonged to genotype 1. The results of this study may aid the surveillance programs aiming at eradicating measles\/rubella virus in Iran, as infections with B19V can be mistakenly reported as measles or rubella if laboratory testing is not conducted.<jats:bold><jats:italic>J. Med. Virol. 88:947\u2013953, 2016<\/jats:italic><\/jats:bold>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24425","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T06:22:58Z","timestamp":1446704578000},"page":"947-953","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence and genotypic characterization of Human Parvovirus B19 in children with measles\u2010 and rubella\u2010like illness in Iran"],"prefix":"10.1002","volume":"88","author":[{"given":"Farhad","family":"Rezaei","sequence":"first","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrang","family":"Sarshari","sequence":"additional","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran 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