{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:36:00Z","timestamp":1784194560657,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Most guidelines suggest combination therapy including nucleoside and nucleotide analogues for the treatment of chronic hepatitis B (CHB) with multidrug resistance (MD\u2010R). However, long\u2010term combination treatment can evoke high costs and safety problems. Therefore, we investigated the efficacy of tenofovir disoproxil fumarate (TDF) mono\u2010rescue therapy for viral suppression in patients with CHB exhibiting MD\u2010R. We reviewed patients with CHB exhibiting antiviral drug resistance treated by TDF mono\u2010rescue therapy from December 2012 to June 2014. The patients were categorized into three groups: lamivudine\u2010resistance (LAM\u2010R) group (n\u2009=\u2009290), and LAM\u2010R\u2009+\u2009adefovir\u2010resistance (ADV\u2010R) group (n\u2009=\u200943), and LAM\u2010R\u2009+\u2009entecavir\u2010resistance (ETV\u2010R) group (n\u2009=\u2009113). We compared the virologic response rate according to the multiplicity of resistance and investigated the predictive factors of a virologic response. For a median of 15 months (range, 6\u201324 months) of TDF mono\u2010rescue therapy, the cumulative virologic response rates were 82.8, 81.4, and 84.1% in the LAM\u2010R, LAM\u2010R\u2009+\u2009ADV\u2010R, and LAM\u2010R\u2009+\u2009ETV\u2010R groups, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.239). Multivariate analysis revealed that multiplicity of resistance did not influence the achievement of a virologic response (<jats:italic>P<\/jats:italic>\u2009=\u20090.218). However, the baseline HBV DNA level significantly influenced the achievement of a virologic response for the treatment of CHB with MD\u2010R (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). TDF mono\u2010rescue therapy is an appropriate treatment for CHB with MD\u2010R, and the baseline HBV DNA level is a significant predictive factor for a virologic response. These factors should be considered before treating CHB with MD\u2010R. <jats:bold><jats:italic>J. Med. Virol. 88:1027\u20131034, 2016<\/jats:italic><\/jats:bold>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24427","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T06:24:39Z","timestamp":1446704679000},"page":"1027-1034","source":"Crossref","is-referenced-by-count":8,"title":["Prediction of virologic response to tenofovir mono\u2010rescue therapy for multidrug resistant chronic hepatitis B"],"prefix":"10.1002","volume":"88","author":[{"given":"Sangheun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Department of Internal Medicine Catholic Kwandong University College of medicine International St. Mary's Hospital Incheon Republic of Korea"},{"name":"Institute for Integrative Medicine Catholic Kwandong University College of medicine International St. Mary's Hospital Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of 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