{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:09Z","timestamp":1740104109365,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jiangsu Province Science and Technology Demonstration Project","award":["BE2015714"],"award-info":[{"award-number":["BE2015714"]}]},{"DOI":"10.13039\/501100010854","name":"Jiangsu Province Health Development Project with Science and Education","doi-asserted-by":"crossref","award":["ZX201109","RC2011084","RC2011085"],"award-info":[{"award-number":["ZX201109","RC2011084","RC2011085"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Province Science and Technology Project of Clinical Medicine","award":["BL2014081"],"award-info":[{"award-number":["BL2014081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Noroviruses (NoVs) are the most common cause of acute gastroenteritis in both sporadic and outbreak cases. Genotyping and recombination analyses were performed in order to help getting more knowledge of the distribution and genetic diversity of NoVs in Suzhou, located in Jiangsu province of China. All stool samples were collected from hospitalized children younger than 5 years old with acute gastroenteritis. For genotyping, the open reading frame (ORF) 1 and ORF2 were partially amplified and sequenced. 26.9% of stool samples were positive for genogroup II NoVs. The most common genotype was GII.4 and its variants included Den Haag\u20102006b, New Orleans\u20102009, and Sydney\u20102012. The Den Haag\u20102006b variants predominated during 2010\u20132012. In 2013, it was replaced by the Sydney\u20102012 variant. The second most common genotype was GII.12\/GII.3. NoVs could be detected throughout the year, with GII.4 and GII.12\/GII.3 coexisting during the cold months, and GII.4 was the main genotype during the warm months. The highest prevalence of NoV was detected in young children aged &lt;24 months. Patients infected with GII.4 had a higher chance of getting moderate fever than other NoV\u2010positive patients, while those infected with GII.12\/GII.3 tended to have a mild degree of fever. NoV is an important pathogen responsible for viral gastroenteritis among children in Suzhou. Analyses of NoV circulating between 2010 and 2013 revealed a change of predominant variant of NoV GII.4 in each epidemic season and intergenotype recombinant strains represented an important part. <jats:bold><jats:italic>J. Med. 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