{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:55:04Z","timestamp":1790463304839,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>A widespread outbreak of enterovirus (EV)\u2010D68 that started in the summer of 2014 has been reported in the USA and Canada. During the course of this outbreak, EV\u2010D68 was identified as a possible cause of acute, unexplained severe respiratory illness and a temporal association was observed between acute flaccid paralysis with anterior myelitis and EV\u2010D68 detection in the upper respiratory tract. In this study, four nasopharyngeal samples collected from patients in Alberta, Canada with a laboratory diagnosis of EV\u2010D68 were used to determine the near full\u2010length genome sequence directly from the specimens. Phylogenetic analysis was performed to study the genotypes and pathogenesis of the circulating strains. Our results support the contention that mutations in the VP1 gene and other regions of the genome causing altered antigenicity, as well as lack of immunity in the younger population, may be responsible for the increased severe respiratory disease outbreaks of EV\u2010D68 worldwide. <jats:bold><jats:italic>J. Med. Virol. 88:1194\u20131203, 2016<\/jats:italic><\/jats:bold>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24444","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T05:25:29Z","timestamp":1449638729000},"page":"1194-1203","source":"Crossref","is-referenced-by-count":5,"title":["Full genome analysis of enterovirus D\u201068 strains circulating in Alberta, Canada"],"prefix":"10.1002","volume":"88","author":[{"given":"Kanti","family":"Pabbaraju","sequence":"first","affiliation":[{"name":"Provincial Laboratory for Public Health Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sallene","family":"Wong","sequence":"additional","affiliation":[{"name":"Provincial Laboratory for Public Health Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Drews","sequence":"additional","affiliation":[{"name":"Provincial Laboratory for Public Health Edmonton Alberta Canada"},{"name":"Department of Pathology and Laboratory Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Tipples","sequence":"additional","affiliation":[{"name":"Provincial Laboratory for Public Health Edmonton Alberta Canada"},{"name":"Department of Medical Microbiology and Immunology University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Tellier","sequence":"additional","affiliation":[{"name":"Provincial Laboratory for Public Health Calgary Alberta Canada"},{"name":"Department of Microbiology, Immunology, and Infectious Diseases University of Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"903","article-title":"Acute flaccid paralysis with anterior myelitis\u2014California, June 2012\u2013June 2014","volume":"63","author":"Ayscue P","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4218-4223.2002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01201\u201014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02982-14"},{"key":"e_1_2_5_7_1","unstructured":"FonsecaK KellnerJ D TalbotJ SimmondsK AnselmoM KuhnS DrewsS FathimaS PabbarajuK TipplesG TellierR WongS.2014. 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