{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:30:42Z","timestamp":1791379842181,"version":"4.3.3"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gen-Probe Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>The sensitivity of E6\/E7 mRNA\u2010based Aptima HPV test (AHPV; Hologic, Inc.) for detection of cervical cancer has been reported based on only a small number of cases. We determined the sensitivity of AHPV in comparison with the DNA\u2010based Hybrid Capture 2 HPV test (HC2; Qiagen) for the detection of oncogenic HPV in a large number of cervical cancers at the time of diagnosis using cervical samples obtained in ThinPrep (Hologic). Samples yielding discordant results were genotyped using Linear Array assay (LA; Roche). Of 396 cases tested, AHPV detected 377 (sensitivity, 95.2%; 95%CI: 93.1\u201397.3), and HC2 376 (sensitivity, 94.9%; 95%CI: 92.7\u201397.1) with an agreement of 97.2% (kappa 0.7; 95%CI: 0.54\u20130.87). Among six AHPV+\/HC2\u2010 cases, LA identified oncogenic HPV types in four including a type 73 and was negative in two. Among five AHPV\u2010\/HC2+ cases, LA detected oncogenic HPV types in two including a type 73 and was negative in three. Of 14 AHPV\u2010\/HC2\u2010 cases, 13 were genotyped. LA detected oncogenic HPV types in six, non\u2010oncogenic types in three, and was negative in four. This is the largest study to demonstrate the sensitivity of AHPV for the detection of invasive cervical cancer and this assay showed equal sensitivity to HC2. <jats:bold><jats:italic>J. Med. Virol. 88:1271\u20131278, 2016<\/jats:italic><\/jats:bold>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24453","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T23:25:04Z","timestamp":1450826704000},"page":"1271-1278","source":"Crossref","is-referenced-by-count":20,"title":["Sensitivity of APTIMA HPV E6\/E7 mRNA test in comparison with hybrid capture 2 HPV DNA test for detection of high risk oncogenic human papillomavirus in 396 biopsy confirmed cervical cancers"],"prefix":"10.1002","volume":"88","author":[{"given":"Partha","family":"Basu","sequence":"first","affiliation":[{"name":"Chittaranjan National Cancer Institute Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanwita","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Chittaranjan National Cancer Institute Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srabani","family":"Mittal","sequence":"additional","affiliation":[{"name":"Chittaranjan National Cancer Institute Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankhadeep","family":"Dutta","sequence":"additional","affiliation":[{"name":"Chittaranjan National Cancer Institute Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Chittaranjan National Cancer Institute Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilarun","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Chittaranjan National Cancer Institute Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Clinical Virology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Chandna","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology AceProbe Technologies (India) Pvt. 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