{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:54Z","timestamp":1786978194191,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002966","name":"Cumhuriyet \u00dcniversitesi","doi-asserted-by":"publisher","award":["T\u2010429"],"award-info":[{"award-number":["T\u2010429"]}],"id":[{"id":"10.13039\/501100002966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Crimean\u2010Congo hemorrhagic fever (CCHF) is a fatal emerging acute viral infection. Not much is known regarding the pathogenic mechanisms and the reasons behind severe or mild disease courses in CCHF. IFN\u2010alpha (IFNA) is one of the essential cytokines in the immune system. Existence of single nucleotide gene polymorphisms (SNPs) in cytokines can cause susceptibility or resistance to viral agents and different clinical courses. Hence, the relationship between SNPs in genes encoding cytokines (\n                      <jats:italic>IFNA1<\/jats:italic>\n                      \u20101823G\/A (rs1332190),\n                      <jats:italic>IFNA5<\/jats:italic>\n                      \u20102529T\/A (rs758236),\n                      <jats:italic>IFNA10<\/jats:italic>\n                      Cys20stop (rs10119910), and\n                      <jats:italic>IFNA17<\/jats:italic>\n                      Ile184Arg (rs9298814) SNPs and disease susceptibility were investigated. The associations between SNPs and CCHF prognosis were also studied. Total 150 patients with CCHF and 170 healthy individuals were enrolled. Genotyping was performed by PCR\u2010RFLP methods. The frequency of\n                      <jats:italic>IFNA1<\/jats:italic>\n                      \u20101823 (rs1332190) GG genotype was significantly higher in control subjects than CCHF patients (20% vs. 8%;\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.01). For\n                      <jats:italic>IFNA17<\/jats:italic>\n                      Ile184Arg (rs9298814) polymorphism, CCHF patients having TG genotype had a higher frequency than the control subjects (38% vs. 32.4%;\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.039). The distribution of TT\u2009+\u2009TG genotype frequencies was also significantly higher in CCHF group than the controls (97.3% vs. 91.8%;\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.049). Genotype and allele frequencies for IFNA subtypes between fatal and survivors were the same (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &gt;\u20090.05). Genotype and allele frequencies between severe and mild\/moderate CCHF patients were also the same (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &gt;\u20090.05). The results show that\n                      <jats:italic>IFNA1<\/jats:italic>\n                      rs1332190 and\n                      <jats:italic>IFNA17<\/jats:italic>\n                      rs9298814 SNPs may play an important role in CCHF susceptibility. Determining the existence of other connections for IFNA SNPs and CCHF severity and fatality requires further investigations.\n                      <jats:bold>\n                        <jats:italic>J. Med. Virol. 88:1159\u20131167, 2016<\/jats:italic>\n                      <\/jats:bold>\n                      . \u00a9 2015 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.24456","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T18:22:52Z","timestamp":1450808572000},"page":"1159-1167","source":"Crossref","is-referenced-by-count":14,"title":["Relationship between\n                    <i>IFNA1<\/i>\n                    ,\n                    <i>IFNA5<\/i>\n                    ,\n                    <i>IFNA10<\/i>\n                    , and\n                    <i>IFNA17<\/i>\n                    gene polymorphisms and Crimean\u2010Congo hemorrhagic fever prognosis in a Turkish population range"],"prefix":"10.1002","volume":"88","author":[{"given":"Nazif","family":"Elaldi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Cumhuriyet University Medical Faculty Research Center (CUTFAM) Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binnur","family":"Bagci","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences Cumhuriyet University Sivas Turkey"},{"name":"Advanced Technology Research and Development Research and Application Center Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izzet","family":"Yelkovan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Bagci","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Gokhan","family":"Gozel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Bakir","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Faculty of Medicine Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Dokmetas","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sisli Etfal Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1099-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2012.1061"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38111"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21222"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2011.623313"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24174"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.45865-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23666"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01383-10"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.019034-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-122"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/521244"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364287"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.10.014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.06.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02469-10"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.01.014"},{"key":"e_1_2_6_19_1","first-page":"S1","article-title":"Crimean\u2010Congo hemorrhagic fever","author":"Elaldi N","year":"2014","journal-title":"J Microbiol Infect Dis"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.07.012"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1143767"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12010"},{"key":"e_1_2_6_23_1","first-page":"570","article-title":"Polymorphism in the interferon\u2010\u03b1 gene family","volume":"59","author":"Golovleva I","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.4.645"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1503.080687"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01146.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.04.016"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-416"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00548-7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.06.020"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0896"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2009.0198"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/1079990041689665"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.02.007"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0966-8"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00530-09"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01320-14"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2006.06.011"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.Supplement_4.S794"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-9-80"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101664"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3282a56a0a"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2004.08.001"},{"key":"e_1_2_6_44_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.7883\/yoken.JJID.2005.358","article-title":"Rapid and quantitative detection of Crimean\u2010Congo hemorrhagic fever virus by one\u2010step real\u2010time reverse transcriptase\u2010PCR","volume":"58","author":"Yapar M","year":"2005","journal-title":"Jpn J Infect Dis"},{"key":"e_1_2_6_45_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/0972-9062.154141","article-title":"Effect of tumour necrosis factor\u2010alpha and interleukin\u20106 promoter polymorphisms on course of Crimean\u2010Congo hemorrhagic fever in Turkish patients","volume":"52","author":"Yilmaz M","year":"2015","journal-title":"J Vector Borne Dis"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24456","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T05:28:39Z","timestamp":1718256519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,6]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/jmv.24456"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24456","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,6]]}}}