{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:17:29Z","timestamp":1791314249913,"version":"4.3.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T00:00:00Z","timestamp":1464825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation for Pediatric Research, Helsinki"},{"name":"Allergy Research Foundation in Southwest Finland, Turku"},{"name":"Sigrid Juselius Foundation, Helsinki"},{"name":"Academy of Finland, Helsinki"},{"name":"Finnish Medical Foundation, Helsinki"},{"name":"Turku University Foundation, Turku"},{"name":"The TYKS Foundation, Turku"},{"name":"Tampere Tuberculosis Foundation, Tampere"},{"name":"Ida Montin Foundation, Espoo"},{"name":"Research Foundation of the Pulmonary Diseases, Helsinki"},{"name":"The Finnish Cultural Foundation, Helsinki; all in Finland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The clinical data on the first wheezing episodes induced by different rhinovirus (RV) species are still limited. We aimed to investigate the prevalence of RV genotypes, sensitization status, and clinical characteristics of patients having a respiratory infection caused by either different RV species or other respiratory viruses. The study enrolled 111 patients (aged 3\u201323 months, 79% hospitalized, 76% with RV infection) with the first wheezing episode. RV\u2010specific sequences were identified by partial sequencing of VP4\/VP2 and 5\u2032 non\u2010coding regions with 80% success rate. The investigated clinical and laboratory variables included atopic characteristics and illness severity, parental atopic illnesses, and parental smoking. Of the study children, 56% percent had\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      1 atopic characteristic (atopy, eczema and\/or blood eosinophil count\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      0.4\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) and 23% were sensitised to allergens. RV\u2010C was detected in 58% of RV positive samples, followed by RV\u2010A (20%) and RV\u2010B (1.2%). Children with RV\u2010A and RV\u2010C induced wheezing were older (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014) and had more atopic characteristics (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) than those with non\u2010RV. RV\u2010A and RV\u2010C illnesses had shorter duration of preadmission symptoms and required more bronchodilator use at the ward than non\u2010RV illnesses (both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05, respectively). RV\u2010C is the most common cause of severe early wheezing. Atopic and illness severity features are associated with children having RV\u2010A or RV\u2010C induced first wheezing episode rather than with children having a non\u2010RV induced wheezing.\n                      <jats:bold>\n                        <jats:italic>J. Med. Virol. 88:2059\u20132068, 2016<\/jats:italic>\n                        .\n                      <\/jats:bold>\n                      \u00a9 2016 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.24587","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T13:32:47Z","timestamp":1464355967000},"page":"2059-2068","source":"Crossref","is-referenced-by-count":33,"title":["Rhinovirus species and clinical characteristics in the first wheezing episode in children"],"prefix":"10.1002","volume":"88","author":[{"given":"Riitta","family":"Turunen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Turku University Hospital Turku Finland"},{"name":"Department of Virology University of Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Jartti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Turku University Hospital Turku 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