{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:08:38Z","timestamp":1762340918457},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:label \/><jats:p>Anti\u2010JCV antibody status is used for PML\u2010risk\u2010stratification in MS patients before and during Natalizumab therapy. JCV antibodies can be detected in around 60% of MS patients, however, only a small proportion actually develop PML. As anti\u2010viral antibodies tend to occur unspecifically, the aim of this study was to correlate JCV antibody status and index with other common anti\u2010viral antibodies. A total of 123 samples of MS\u2010patients were tested for anti\u2010JCV antibodies by JCV\u2010Stratify\u2010ELISA at Unilabs, Denmark. The same samples were analyzed for measles, rubella, varicella zoster, EBV, and CMV IgG and IgM antibodies by ELISA, or chemiluminescence\u2010microparticle immunoassay. For all antibody\u2010titers correlations were calculated and group comparisons of JCV\u2010positive and \u2010negative patients were performed. Fifty\u2010three patients (43.1%) were JCV negative and 70 (56.9%) positive. CMV\u2010IgM antibodies were detected in six patients. Otherwise no IgM antibodies were detected. IgG antibodies against measles, rubella, varicella zoster, and EBV were detected in \u226597% of patients and 47 samples (38.2%) tested positive for CMV\u2010IgG. There was no significant correlation between any of the antibody titers including JCV index, however, a significantly higher prevalence (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) of CMV\u2010IgG in JCV positive compared to JCV negative patients, whereas no difference was detected for measles, rubella, varicella zoster, and EBV IgG. In conclusion, the JCV antibody response in MS patients seems to be largely independent of any other anti\u2010viral immunity. The only coincidence was found with CMV IgG antibodies which might point towards some immunological cross\u2010reactivity in anti\u2010viral immune response or other mechanisms leading to combined viral infections such as shared transmission. <jats:bold><jats:italic>J. Med. Virol. 89:3\u20139, 2017<\/jats:italic><\/jats:bold>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24590","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T17:34:15Z","timestamp":1464888855000},"page":"3-9","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between anti\u2010JC\u2010virus and anti\u2010cytomegalovirus, \u2010Epstein\u2013Barr virus and \u2010measles\/\u2010rubella\/\u2010varicella\u2013zoster\u2010virus antibodies"],"prefix":"10.1002","volume":"89","author":[{"given":"Michael","family":"Auer","sequence":"first","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wegene","family":"Borena","sequence":"additional","affiliation":[{"name":"Department of Virology Innsbruck Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothee","family":"Holm\u2010von Laer","sequence":"additional","affiliation":[{"name":"Department of Virology Innsbruck Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Deisenhammer","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.24.3083"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-010-9201-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550289809113482"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107829"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12304"},{"key":"e_1_2_5_7_1","first-page":"185","volume-title":"Neurobiology of disease","author":"Brooks B","year":"2011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2006.04.213"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05228-11"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/143.2.188"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws260"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.25127"},{"key":"e_1_2_5_13_1","first-page":"591","article-title":"Prevalence of measles, rubella, mumps, and varicella antibodies among healthcare workers in Japan","volume":"25","author":"Hatakeyama S","year":"2004","journal-title":"Inf Control"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.2171"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.02.002"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(92)80048-L"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82094-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.16.25.19896-en"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300174"},{"key":"e_1_2_5_20_1","first-page":"117","article-title":"Stratification and monitoring of natalizumab\u2010associated progressive multifocal leukoencephalopathy risk: Recommendations from an expert group","volume":"87","author":"McGuigan C","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513477925"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6487-5"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24286"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-40-23"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196110262651701"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-008-1005-6"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/656918"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400044983"},{"key":"e_1_2_5_29_1","unstructured":"STRATIFY JCVTM DxSelect\u2122 user manual2013. 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