{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:15:10Z","timestamp":1791314110477,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Although acute gastroenteritis is a major public health problem worldwide, \u223c40% of the cases remain undiagnosed for any etiological agent. Human Bocavirus (HBoV) has been detected frequently in feces of diarrhoeic children suggesting its possible etiological involvement in the disease. HBoV has not been reported in association with acute gastroenteritis from India. Fecal samples (n\u2009=\u2009418) collected from children (age \u22645 years) hospitalized with acute gastroenteritis, between January 2009 and December 2011, from three local hospitals were examined for presence of HBoV using PCR targeting the partial VP1\/VP2 capsid region (\u223c575\u2009bp) followed by phylogenetic analysis. HBoV was detected in 24\/418 (5.7%) cases. Co\u2010infection was observed in 5\/24 (21%) cases. HBoV infections occurred in children \u226412 months of age. Peak HBoV activity was observed in monsoon and post monsoon season. All four HBoV genotypes were detected in the study region. Major clinical symptoms of HBoV mono infections included diarrhoea (100%), fever (90%), dehydration (74%), and vomiting (58%). Dehydration was observed in all of the HBoV2\u20134 cases and in 50% of the HBoV1 cases. Clinical severity varied with genotype (HBoV2\u2009&gt;\u2009HBoV1\u2009&gt;\u2009HBoV3\u2009&gt;\u2009HBoV4). HBoV2 cases recorded severe and very severe infections. The study illustrates prevalence and vast genetic diversity of HBoVs in acute gastroenteritis. It highlights the clinical features of HBoV1\u20134 infections and sheds light on clinical impact of HBoV genotypes in gastroenteritis. <jats:bold><jats:italic>J. Med. Virol. 89:17\u201323, 2017<\/jats:italic><\/jats:bold>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24593","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T11:07:30Z","timestamp":1465384050000},"page":"17-23","source":"Crossref","is-referenced-by-count":28,"title":["Molecular epidemiology and clinical severity of Human Bocavirus (HBoV) 1\u20134 in children with acute gastroenteritis from Pune, Western India"],"prefix":"10.1002","volume":"89","author":[{"given":"Neha","family":"Lasure","sequence":"first","affiliation":[{"name":"Department of Enteric Viruses National Institute of Virology Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varanasi","family":"Gopalkrishna","sequence":"additional","affiliation":[{"name":"Department of Enteric Viruses National Institute of Virology Pune 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