{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:59:51Z","timestamp":1790517591305,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical Research Grant from the Reims University Medical Centre","award":["EA4684-CardioVir"],"award-info":[{"award-number":["EA4684-CardioVir"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>We assessed Enterovirus (EV) &amp;Parvovirus B19 (PVB19) genomes and CD3, CD68&amp;HLA\u2010DR detection in dilated cardiomyopathies (DCM). EV&amp;PVB19 genomes and CD3, CD68&amp;HLA\u2010DR were detected by PCR and immunohistochemistry assays in 115 endomyocardial biopsies obtained in 13 idiopathic DCM (iDCM) and 10 explained DCM (eDCM) patients. Results were compared with those of 47 atrial surgical samples (47 surgery controls) and 22 autoptic cardiac samples (11 healthy heart controls) (2008\u20132014, Reims, France). EV was detected in 23.1% of iDCM patients but not in eDCM and controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) (viral load 803 copies\/\u03bcg). PVB19 was detected in 76.9%, 80.0%, 63.6% and 78.2% of iDCM, eDCM, healthy heart and surgery controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.99) with a mean viral load of 413, 346, 1,428, and 71 copies\/\u03bcg. CD3, CD68 or HLA\u2010DR were detected in 100 and 50% of EV and PVB19 \u201cmono\u2010infected\u201d iDCM patients. EV was exclusively detected in iDCM cases in association with CD3, CD68, or HLA\u2010DR indicating that EV could be an etiological cause in a subset of iDCM cases. By contrast the equal frequent detection of PVB19 in iDCM cases and controls without association with CD3, CD68, or HLA\u2010DR suggested that PVB19 could be a bystander in many DCM cases. <jats:bold><jats:italic>J. Med. Virol. 89:55\u201363, 2017<\/jats:italic><\/jats:bold>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24600","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T17:42:46Z","timestamp":1466012566000},"page":"55-63","source":"Crossref","is-referenced-by-count":14,"title":["Enterovirus but not Parvovirus B19 is associated with idiopathic dilated cardiomyopathy and endomyocardial CD3, CD68, or HLA\u2010DR expression"],"prefix":"10.1002","volume":"89","author":[{"given":"Yohan","family":"N'Guyen","sequence":"first","affiliation":[{"name":"Laboratoirede Virologie m\u00e9dicale et mol\u00e9culaire Centre hospitalier universitaire de Reims France"},{"name":"EA\u20104684 Cardiovir Facult\u00e9 de m\u00e9decine Universit\u00e9 de Reims Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lesaffre","sequence":"additional","affiliation":[{"name":"EA\u20104684 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