{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:34:20Z","timestamp":1784802860158,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>The purpose of this study was to report a case of a previously healthy 20\u2010year\u2010old woman diagnosed with splenic infarction following infectious mononucleosis (IM) by Epstein\u2013Barr virus (EBV) infection and to perform the first systematic review of the clinical characteristics of splenic infarction associated with IM. A systematic review was conducted using English, French, and Japanese literatures of splenic infarction associated with IM due to EBV infection published between 1961 and 2015 in PubMed Medline. A total of 19 cases were extracted from the collected articles. Left upper quadrant (LUQ) pain was observed in 15 (79%) patients. Splenectomy was performed in five (26%) cases, among which four patients presented with stable vital signs. Splenic rupture was accompanied in two (10%) patients. The median time from the onset of IM symptoms to the diagnosis of splenic infarction was 5 days (range, 1\u201325 days). Fourteen (74%) of 19 patients experienced improvement through medical treatment, and there were no deaths. Splenic infarction associated with IM due to EBV infection can show a favorable clinical outcome after medical treatment. Clinicians should consider the possibility of splenic infarction when patients with IM experience LUQ pain. <jats:bold><jats:italic>J. Med. Virol. 89:332\u2013336, 2017<\/jats:italic>.<\/jats:bold> \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24618","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T11:37:27Z","timestamp":1467286647000},"page":"332-336","source":"Crossref","is-referenced-by-count":25,"title":["Splenic infarction associated with acute infectious mononucleosis due to Epstein\u2013Barr virus infection"],"prefix":"10.1002","volume":"89","author":[{"given":"Dae\u2010Hyuk","family":"Heo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chonbuk National University Hospital Jeonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Youb","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonbuk National University Hospital Jeonju Republic of 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