{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:06:27Z","timestamp":1791317187568,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japanese Ministry of Health, Labour, and Welfare","award":["[KHC1102]"],"award-info":[{"award-number":["[KHC1102]"]}]},{"name":"Public-Private Sector Joint Research on Publicly Essential Drugs","award":["[KHC1102]"],"award-info":[{"award-number":["[KHC1102]"]}]},{"name":"Research Foundation for Microbial Diseases"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Age\u2010related declines in cell\u2010mediated immunity (CMI) are associated with the incidence and severity of Herpes Zoster (HZ) infection. However, the level of Varicella\u2013Zoster virus (VZV)\u2010specific CMI associated with disease onset is unclear. This study aimed to examine factors associated with VZV\u2010specific CMI, as measured by an interferon\u2010gamma (IFN\u2010\u03b3) enzyme\u2010linked immunospot (ELISPOT) assay, in a Japanese cohort. The study enrolled 365 subjects aged 60 years and over, all of whom were taking part in the Shozu Herpes Zoster (SHEZ) study and had undergone four sets of blood and intradermal reaction tests during a 3\u2009year follow\u2010up period. The VZV\u2010specific immunity profile of each subject was assessed, and linear mixed effects models were constructed to analyze IFN\u2010\u03b3 ELISPOT results in association with a combination of factors. The model that best explained the IFN\u2010\u03b3 ELISPOT results was selected using the Akaike Information Criteria. The best\u2010fit model consisted of age group as the only explanatory fixed\u2010effect variable. The model showed that VZV\u2010specific CMI, quantified as numbers of spots on the ELISPOT assay, among subjects aged 70\u201379 was on average 10.30 points lower than that among subjects aged 60\u201369. There was no statistically significant difference between subjects aged 70\u201379 and those aged 80\u201389. Age was the only factor significantly associated with the level of VZV\u2010specific CMI, as measured by the IFN\u2010\u03b3 ELISPOT assay. These results may represent an important step towards quantifying the relationship between VZV\u2010specific CMI and the onset of HZ. <jats:bold><jats:italic>J. Med. Virol. 89:313\u2013317, 2017<\/jats:italic>.<\/jats:bold> \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24629","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T20:25:14Z","timestamp":1468614314000},"page":"313-317","source":"Crossref","is-referenced-by-count":14,"title":["Relationship between cell\u2010mediated immunity to Varicella\u2013Zoster virus and aging in subjects from the community\u2010based Shozu Herpes Zoster study"],"prefix":"10.1002","volume":"89","author":[{"given":"Risako","family":"Shirane","sequence":"first","affiliation":[{"name":"Division of Clinical Virology, Center for Infectious Diseases Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamin","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Clinical Virology, Center for Infectious Diseases Kobe University Graduate School of Medicine Kobe 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