{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:15:39Z","timestamp":1783545339550,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Research System (AES)","award":["PI12-00904"],"award-info":[{"award-number":["PI12-00904"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>The epidemiology and clinical association of enterovirus (EV) and parechovirus (HPeV) infections, as well as the type\u2010distribution\u2010according\u2010to\u2010age, were determined during a 4\u2010year study period in Spain. During 2010\u20132013, a total of 21,832 clinical samples were screened for EV and the detection frequency was 6.5% (1,430). Of the total EV\u2010negative samples, only 1,873 samples from 2011 to 2013 were available for HPeV testing. HPeV was detected in 42 (2%) of them. Positive samples were genotyped using PCR and sequencing. EV infections occurred in all age groups of patients: neonates (17%), children 28 days to 2 years (29%), children 2\u201314 years (40%), and adults (14%). Thirty\u2010four different EV types were identified. HPeV infections were detected exclusively in infants &lt;8\u2009m (70% neonates, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05). All but one HPeV were HPeV\u20103. Differences in type frequency detection were found according to age and clinical manifestation. Coxsackievirus (CV)\u2010B4 (61%), CV\u2010B5 (83%), and HPeV\u20103 (64%) were more frequent in neonates than in older patients (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05). Echovirus (E)\u20103 (60%), E\u201018 (47%), E\u201025 (62%), CV\u2010A6 (61%), CV\u2010A16 (72%), and EV\u201071 (75%) were mainly detected in children 28 days to 2 years (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05), whereas, E\u20106 (79%), E\u201020 (88%), and E\u201030 (85%) were predominant in children &gt;2 years and adults (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05). Clinically, meningitis was associated with EV (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01) whereas, encephalitis was more frequent in HPeV\u2010infected patients. CV\u2010B types were associated with myocarditis (90%; <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05) and EV species A with hand\u2013foot\u2013mouth\u2010disease\/atypical exanthema (88%; <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05). <jats:bold><jats:italic>J. Med. Virol. 89:435\u2013442, 2017<\/jats:italic>.<\/jats:bold> \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24658","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T22:42:45Z","timestamp":1470782565000},"page":"435-442","source":"Crossref","is-referenced-by-count":44,"title":["Molecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4\u2010year period in Spain"],"prefix":"10.1002","volume":"89","author":[{"given":"Mar\u00eda","family":"Cabrerizo","sequence":"first","affiliation":[{"name":"National Centre for Microbiology Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"D\u00edaz\u2010Cerio","sequence":"additional","affiliation":[{"name":"National Centre for Microbiology Instituto de Salud Carlos III Madrid 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