{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:20:20Z","timestamp":1770834020105,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T00:00:00Z","timestamp":1475193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Human rhinovirus (RV) is commonly associated with severe acute lower respiratory infections (ALRI) in children. We aimed to describe the distribution of RV species and associations between RV species and clinical features in children hospitalized with clinically severe pneumonia (CSP) in Morocco. Nasopharyngeal aspirates (NPAs) were collected from 700 children, 2\u201359 months of age, admitted with CSP to the H\u00f4pital d'Enfants de Rabat in Morocco. At least one respiratory virus was identified in 92% of children, of which RV was the most common (53%). PCR assays, sequencing, and phylogenetic tree analyses were carried out on 183 RV\u2010positive NPAs to determine RV species and genotypes. Of 157 successfully genotyped NPAs, 60 (38.2%) were RV\u2010A, 8 (5.1%) were RV\u2010B, and 89 (56.7%) were RV\u2010C. Wheezing and cyanosis were more common in RV\u2010C\u2010positive than RV\u2010A\u2010positive children (80.9% vs. 56.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001 for wheezing and 10.1% vs. 0%; <jats:italic>P<\/jats:italic>\u2009=\u20090.011 for cyanosis). Physician's discharge diagnosis of pneumonia was more frequent among RV\u2010A\u2010positive (40.0%) than RV\u2010C\u2010positive children (20.2%; <jats:italic>P<\/jats:italic>\u2009=\u20090.009). RV\u2010A and RV\u2010C showed distinct seasonal patterns. Our findings suggest that RV\u2010C is associated with wheezing illness while RV\u2010A is associated with pneumonia. <jats:italic><jats:bold>J. Med. Virol. 89:582\u2013588, 2017<\/jats:bold><\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24684","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T12:09:03Z","timestamp":1475064543000},"page":"582-588","source":"Crossref","is-referenced-by-count":14,"title":["Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco"],"prefix":"10.1002","volume":"89","author":[{"given":"Alicia A.","family":"Annamalay","sequence":"first","affiliation":[{"name":"School of Paediatrics and Child Health University of Western Australia Perth Australia"},{"name":"Telethon Kids Institute University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imane","family":"Jroundi","sequence":"additional","affiliation":[{"name":"ISGlobal, Barcelona Ctr. Int. Health Res. 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