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The present study describes the seroepidemiological analysis of circulating EVs in Ireland from 2005 to 2014 and phylogenetic characterization of echovirus 30 (E\u201030), enterovirus A71 (EV\u2010A71), and enterovirus D68 (EV\u2010D68). EV VP1 genotyping was applied to viral isolates and clinical samples, including cerebrospinal fluid (CSF), and those isolates that remained untypeable by neutralising anti\u2010sera. An increase in AM cases from 2010 to 2014 was associated with an E\u201030 genogroup variant VII and sequences clustered phylogenetically with those detected in AM outbreaks in France and Italy. EV\u2010D68 viral RNA was not detected in CSF samples and no neurological involvement was reported. Three EV\u2010A71 positive CSF samples were identified in patients presenting with AM. A phylogenetic analysis of respiratory\u2010associated EV\u2010D68 and EV\u2010A71 cases in circulation was performed to determine baseline epidemiological data. EV\u2010D68 segregated with clades B and B(1) and EV\u2010A71 clustered as subgenogroup C2. The EV VP1 genotyping method was more sensitive than neutralising anti\u2010sera methods by virus culture and importantly demonstrated concordance between EV genotypes in faecal and CSF samples which should facilitate EV screening by less invasive sampling approaches in AM presentations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24765","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:27:06Z","timestamp":1484044026000},"page":"1550-1558","source":"Crossref","is-referenced-by-count":11,"title":["Seroepidemiological and phylogenetic characterization of neurotropic enteroviruses in Ireland, 2005\u20102014"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5048-5021","authenticated-orcid":false,"given":"Jorge Abboud","family":"Guerra","sequence":"first","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Waters","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Kelly","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Morley","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"O'Kelly","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Dean","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Cunney","sequence":"additional","affiliation":[{"name":"Health Protection Surveillance Centre Dublin Ireland"},{"name":"Children's University Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piaras","family":"O'Lorcain","sequence":"additional","affiliation":[{"name":"Health Protection Surveillance Centre Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Cotter","sequence":"additional","affiliation":[{"name":"Health Protection Surveillance Centre Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Connell","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"O'Gorman","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Hall","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Carr","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cillian F.","family":"De Gascun","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory University College Dublin Belfield Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2012.10.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.971"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0252"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.1941-1948.1999"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1170-1174.2000"},{"volume-title":"Polio laboratory manual","year":"2004","key":"e_1_2_6_7_1"},{"key":"e_1_2_6_8_1","unstructured":"CotterS O'LorcainP. 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