{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:37:15Z","timestamp":1767008235928,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Rubella causes disease in the fetus. Immunity to rubella is therefore, routinely screened in pregnant women. In this retrospective observational study, we assessed the levels of potential susceptibility to rubella in the population of a north London antenatal clinic. Risk factors for potential susceptibility to rubella and changes in potential susceptibility to rubella over time were studied. Almost all women were screened for potential susceptibility to rubella (99.8%). The majority were predicted to be immune (96.8%). Women booking in later years within the study period showed higher levels of potential susceptibility to rubella. Booking during each subsequent year in the study gave women an odds ratio of 0.91 (CI:0.84, 0.98, <jats:italic>P<\/jats:italic>\u2009=\u20090.009) of being predicted to have immunity against rubella. Age was associated with predicted immunity to rubella, with a 5.1% (CI:3.3%, 6.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) increased likelihood for every year older. Previous pregnancy was predictive of immunity against rubella with an odds ratio of 1.41 (CI 1.21, 1.61, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Those from a non\u2010white ethnicity were less likely to have antibodies predictive of immunity (OR: 0.730, CI: 0.581, 0.879 <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001). Country of birth was associated with differences in potential susceptibility, with those being born outside of the British Isles having an odds ratio for predicted immunity of 0.63 (CI:0.35,0.91, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Being born in a high\u2010risk country for rubella non\u2010immunity was also a risk factor, giving an odds ratio of predicted immunity to rubella of 0.55 (CI:0.32, 0.77, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24818","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T10:41:51Z","timestamp":1490956911000},"page":"1532-1538","source":"Crossref","is-referenced-by-count":7,"title":["Screening for potential susceptibility to rubella in an antenatal population: A multivariate analysis"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-9497","authenticated-orcid":false,"given":"Luke Blagdon","family":"Snell","sequence":"first","affiliation":[{"name":"Department of Virology Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colette","family":"Smith","sequence":"additional","affiliation":[{"name":"HIV Clinical Epidemiology and Biostatistics Group University College London Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Chaytor","sequence":"additional","affiliation":[{"name":"Department of Virology Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"McRae","sequence":"additional","affiliation":[{"name":"Information and Governance Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauli","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Virology Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Department of Virology Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"343","volume-title":"The Green Book 2nd edition, Public Health England","author":"Salisbury D","year":"2013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2807\/esm.09.04.00464-en"},{"key":"e_1_2_8_4_1","first-page":"2015","article-title":"Congenital rubella in british paediatric surveillance unit","author":"Tookey PA","year":"2014","journal-title":"Ann Rep"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.6.1176"},{"key":"e_1_2_8_6_1","unstructured":"Public Health England. (2016) Press release: Rubella susceptibility screening in pregnancy to end in England Cited: 27 January 2016 Available from:https:\/\/www.gov.uk\/government\/news\/rubella-susceptibility-screening-in-pregnancy-to-end-in-england"},{"key":"e_1_2_8_7_1","unstructured":"World Health Organization. (2012) Global measles and rubella strategic plan: 2012\u20132020. Geneva: 2012. 42 p."},{"key":"e_1_2_8_8_1","unstructured":"World Health Organisation. [Internet] 2016 WHO immunization schedule by country Available from:http:\/\/www.who.int\/immunization\/monitoring_surveillance\/data\/en\/"},{"key":"e_1_2_8_9_1","unstructured":"UK National Screening Commitee. (2003) Infectious diseases in pregnancy screening programme. handbook for laboratories; 2003."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00383-16"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.12.022"},{"key":"e_1_2_8_12_1","unstructured":"World Health Organisation Europe. 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