{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:28:21Z","timestamp":1792600101345,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Letten Foundation Norway"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Although anogenital cancers have been on a gradual rise in developing countries in the past few decades, they have been understudied. The objective was to investigate genotypic diversity of anogenital HPV amongst women reporting for routine cervical cancer screening in Harare in Zimbabwe. A cross\u2010sectional study that enrolled 144 women \u226518 years from a cervical cancer\u2010screening clinic was performed. Each woman provided a self\u2010collected cervico\u2010vaginal swab (VS) and a clinician\u2010collected anal swab (CCAS). HIV testing was offered and cervical cytology was performed. Both VS and CCAS samples were HPV genotyped, using amplicon sequencing of the L1 gene region with Illumina technology. Mean age of the women was 39.9 (range 18\u201083 years, SD\u2009\u00b1\u200911.0). HPV prevalence was 72% (104\/144) in VS and 48% (69\/144) in CCAS. The most common genotypes detected in both VS and CCAS were HPV18, HPV52, and HPV16. Sixty two percent of the subjects had multiple genotypic HPV infections. The odds of being HPV\u2010positive among HIV\u2010infected women were higher than in HIV\u2010negative women in both the vagina and the anus (CCAS OR\u2009=\u20094.8; CI 2.4\u20109.8,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and (VS OR\u2009=\u20092.9; CI 1.3\u20106.4,<jats:italic>P<\/jats:italic>\u2009=\u20090.005). High HPV prevalence and diverse genotypes were detected in both the vagina and anus. Anal oncogenic HPV infection was common. HPV 52 was one of the most common oncogenic genotypes in both the vagina and anus. HIV co\u2010infection played a significant role in the prevalence of HPV. These data have implications for design of primary and secondary programs for prevention of anogenital cancer in Zimbabwe.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24825","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T09:38:41Z","timestamp":1491644321000},"page":"1671-1677","source":"Crossref","is-referenced-by-count":16,"title":["Genotypic diversity of anogenital human papillomavirus in women attending cervical cancer screening in Harare, Zimbabwe"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-6829","authenticated-orcid":false,"given":"Racheal S.","family":"Dube Mandishora","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology College of Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene K.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyasha","family":"Chin'ombe","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology College of Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerina","family":"Duri","sequence":"additional","affiliation":[{"name":"Department of Immunology College of Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Ngara","sequence":"additional","affiliation":[{"name":"Department of Community Medicine College of Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine B.","family":"Rounge","sequence":"additional","affiliation":[{"name":"Department of Research Cancer Registry of Norway Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Meisal","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole H.","family":"Ambur","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Palefsky","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babill","family":"Stray\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Women's Clinic Rikshospitalet Oslo University Hospital and Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvavahera M.","family":"Chirenje","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology College of Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"485","article-title":"Papillomaviruses in human disease: part II. 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