{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:14:25Z","timestamp":1777022065606,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Respiratory syncytial virus (RSV) is an important cause of acute lower respiratory tract infection (ALRI) in infants and young children globally. RSV presents two antigenic groups RSV\u2010A and \u2010B. Genetic variability is also very high within each group. RSV circulation varies year to year and even varies among different regions. Data on circulatory pattern of RSV are available from other parts of India except Kerala. The aim of the study was to generate data about groups and genotypes of circulating RSV in Kerala. In this study, RSV positive samples received during January, 2012 to December, 2014 were used for genetic characterization. The samples were tested by using nucleocapsid (N) gene\u2010based conventional multiplex reverse transcriptase polymerase chain reaction (RT\u2010PCR) to identify the RSV group. Genotyping was done by nucleotide sequencing of the C\u2010terminal region of the glycoprotein (G) gene. Out of the 130 patient samples tested, 49 samples were positive for RSV. Among the positive samples, 32 belong to the RSV\u2010A and 17 belong to RSV\u2010B virus. Phylogenetic analysis revealed that all RSV\u2010A sequences (<jats:italic>n<\/jats:italic>\u2009=\u200922) belonged to NA1 genotype and five of the sequences showed the novel 72 nucleotide duplication and clustered into the newly designated ON1 genotype. All RSV\u2010B sequences (<jats:italic>n<\/jats:italic>\u2009=\u200917) were clustered into the BA (BA9 and 10) genotype. From this study, we concluded both RSV\u2010A and \u2010B were co\u2010circulated in Kerala and RSV\u2010A was observed predominantly in 2012 and RSV\u2010B in 2014. As per our best of knowledge, BA10 genotype is first observed in India.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24842","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T16:14:46Z","timestamp":1493741686000},"page":"2092-2097","source":"Crossref","is-referenced-by-count":8,"title":["Genetic characterization respiratory syncytial virus in Kerala, the southern part of India"],"prefix":"10.1002","volume":"89","author":[{"given":"Savita L.","family":"Patil","sequence":"first","affiliation":[{"name":"BSL\u20104 Laboratory, Microbial Containment Complex National Institute of Virology Pashan, Pune Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-4391","authenticated-orcid":false,"given":"Anukumar","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"National Institute of Virology Kerala Unit Govt. T.D. 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