{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:27:22Z","timestamp":1791278842071,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["5U51IP000155"],"award-info":[{"award-number":["5U51IP000155"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:label\/><jats:p>Enteroviruses can cause outbreaks of severe acute respiratory illness (SARI) and EV\u2010A, \u2010B, \u2010C, and \u2010D species have different pathogenic profiles and circulation patterns. We aimed to characterize and determine the prevalence of enterovirus genotypes among South African patients with respiratory illness and controls during June 2012 to July 2014. Syndromic SARI and influenza\u2010like illness (ILI) surveillance was performed at two sentinel sites. At each site nasopharyngeal\/oropharyngeal specimens were collected from SARI and ILI patients as well as controls. Specimens were tested for enterovirus by real\u2010time PCR. Positive specimens were further genotyped by sequencing a region of the VP1 gene. The prevalence of enterovirus was 5.8% (87\/1494), 3.4% (103\/3079), and 3.4% (46\/1367) among SARI, ILI, and controls, respectively (SARI\/controls, <jats:italic>P<\/jats:italic>\u2009=\u20090.002 and ILI\/control, <jats:italic>P<\/jats:italic>\u2009=\u20090.973). Among the 101\/236 (42.8%) enterovirus\u2010positive specimens that could be genotyped, we observed a high diversity of circulating enterovirus genotypes (a total of 33 genotypes) from all four human enterovirus species with high prevalence of Enterovirus\u2010B (60.4%; 61\/101) and Enterovirus\u2010A (21.8%; 22\/101) compared to Enterovirus\u2010C (10.9%; 11\/101) and Enterovirus\u2010D (6.9%; 7\/101) (<jats:italic>P<\/jats:italic>\u2009=\u20090.477). Of the enterovirus genotypes identified, Echovirus 30 (9.9%, 10\/101), Coxsackie virus B5 (7.9%, 8\/101) and Enterovirus\u2010D68 (6.9%, 7\/101) were most prevalent. There was no difference in disease severity (SARI or ILI compared to controls) between the different enterovirus species (<jats:italic>P<\/jats:italic>\u2009=\u20090.167). We observed a high number of enterovirus genotypes in patients with respiratory illness and in controls from South Africa with no disease association of EV species with disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24869","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T12:53:02Z","timestamp":1496407982000},"page":"1759-1767","source":"Crossref","is-referenced-by-count":24,"title":["Enterovirus genotypes among patients with severe acute respiratory illness, influenza\u2010like illness, and asymptomatic individuals in South Africa, 2012\u20102014"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-8927","authenticated-orcid":false,"given":"Orienka","family":"Hellferscee","sequence":"first","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa"},{"name":"University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Tempia","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa"},{"name":"Centres for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibongile","family":"Walaza","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa"},{"name":"University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Variava","sequence":"additional","affiliation":[{"name":"University of the Witwatersrand Johannesburg South Africa"},{"name":"Department of Medicine Klerksdorp\u2010Tshepong Hospital Complex Klerksdorp South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Dawood","sequence":"additional","affiliation":[{"name":"Pietermaritzburg Metropolitan Hospital Pietermaritzburg South Africa"},{"name":"Caprisa University of KwaZulu\u2010Natal South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Wolter","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa"},{"name":"University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabir A.","family":"Madhi","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa"},{"name":"University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mignon","family":"du Plessis","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa"},{"name":"University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Cohen","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa"},{"name":"University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florette K.","family":"Treurnicht","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"890","article-title":"Childhood pneumonia\u2014progress and challenges","volume":"96","author":"Zar H J","year":"2006","journal-title":"S Afr Med J"},{"key":"e_1_2_7_3_1","unstructured":"WHO.2015. 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