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To evaluate the changes in the glycemic state following Sofosbuvir\u2010based treatment regimens in diabetic HCV patients. Four hundred chronic hepatitis C patients who underwent Sofosbuvir\u2010based treatment regimens were retrospectively screened. Sixty\u2010five diabetic HCV patients only enrolled in our analysis. Baseline demographic and laboratory data were recorded. Pretreatment Transient elastography was performed. At 24\u2010week post EOT (SVR24), Fasting Plasma glucose, and Hemoglobin A1c were re\u2010evaluated and compared with baseline. All enrolled diabetic patients were responders. They showed statistically significant decline in Fasting Plasma glucose and Hemoglobin A1c values at SVR24. Whatever the degree of hepatic fibrosis, the level of Fasting Plasma glucose and Hemoglobin A1c decreased at SVR24 in comparison to baseline level. Fifty\u2010one patients showed improvement in their Hemoglobin A1c values at SVR24 and this improvement was more likely to occur among patients with low Body mass index. The reduction in Fasting Plasma glucose &gt;20\u2009mg\/dL (&gt;1.1\u2009mmol\/L) and Hemoglobin A1c <jats:bold>\u2265<\/jats:bold>0.5% was not associated with age, gender or hepatic fibrosis stage. Sofosbuvir\u2010based regimens are a highly efficient antiviral therapy for diabetic chronic HCV patients resulted in improvement in Fasting Plasma glucose and Hemoglobin A1c.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24897","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T13:42:38Z","timestamp":1499521358000},"page":"2181-2187","source":"Crossref","is-referenced-by-count":38,"title":["Improvement of glycemic state among responders to Sofosbuvir\u2010based treatment regimens: Single center experience"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3612-0130","authenticated-orcid":false,"given":"Shereen","family":"Abdel Alem","sequence":"first","affiliation":[{"name":"Endemic Medicine and Hepatology Department Faculty of medicine Cairo University Cairo Egypt"},{"name":"Kasr Al\u2010Ainy viral hepatitis Centre Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Endemic Medicine and Hepatology Department Faculty of medicine Cairo University Cairo Egypt"},{"name":"Kasr Al\u2010Ainy viral hepatitis Centre Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab","family":"Fouad","sequence":"additional","affiliation":[{"name":"Endemic Medicine and Hepatology Department Faculty of medicine Cairo University Cairo Egypt"},{"name":"Kasr Al\u2010Ainy viral hepatitis Centre Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Adel","sequence":"additional","affiliation":[{"name":"Kasr Al\u2010Ainy viral hepatitis Centre Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Abdellatif","sequence":"additional","affiliation":[{"name":"Endemic Medicine and Hepatology Department Faculty of medicine Cairo University Cairo Egypt"},{"name":"Kasr Al\u2010Ainy viral hepatitis Centre Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherief","family":"Musa","sequence":"additional","affiliation":[{"name":"Endemic Medicine and Hepatology Department Faculty of medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Nagy","sequence":"additional","affiliation":[{"name":"Kasr Al\u2010Ainy viral hepatitis Centre Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad S.","family":"Hussein","sequence":"additional","affiliation":[{"name":"Kasr Al\u2010Ainy viral hepatitis Centre Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Yosry","sequence":"additional","affiliation":[{"name":"Endemic Medicine and Hepatology Department Faculty of medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"Esmat","sequence":"additional","affiliation":[{"name":"Endemic Medicine and Hepatology Department Faculty of medicine Cairo University Cairo Egypt"},{"name":"Kasr Al\u2010Ainy viral hepatitis Centre Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"International Diabetes Federation. 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