{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:05:31Z","timestamp":1759385131858,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Does anal HPV viral load explain the difference in anal HPV persistence between HIV\u2010negative and \u2010positive men who have sex with men (MSM)? MSM \u226518 years were recruited in Amsterdam, the Netherlands, in 2010\u20102011. Anal self\u2010swabs were collected every 6 months and genotyped (SPF<jats:sub>10<\/jats:sub>\u2010PCR\u2010DEIA\u2010LIPA<jats:sub>25<\/jats:sub>\u2010system). HPV16 and HPV18 load was determined with a type specific quantitative (q)PCR, and compared between HIV\u2010negative and \u2010positive men using ranksum test. Persistence was defined as \u22653 positive samples for the same HPV\u2010type. Determinants of persistent HPV16\/18 infection and its association with HPV16\/18 load were assessed with logistic regression. Of 777 recruited MSM, 54 and 22 HIV negative men were HPV16 and HPV18 positive at baseline, and 64 and 39 HIV\u2010positive MSM. The geometric mean titer (GMT) of HPV16 was 19.6 (95%CI 10.1\u201038.0) and of HPV18 8.6 (95%CI 2.7\u201027.5) DNA copies\/human cell. HPV16 and HPV18 load did not differ significantly between HIV\u2010negative and \u2010positive MSM (<jats:italic>P<\/jats:italic>\u2009=\u20090.7; <jats:italic>P<\/jats:italic>\u2009=\u20090.8, respectively). In multivariable analyses HPV16 load was an independent determinant of HPV16 persistence (OR 1.8, 95%CI 1.3\u20102.4). No difference in anal HPV viral load was found between HIV\u2010positive and HIV\u2010negative MSM. HPV 16\/18 viral load is an independent determinant of type\u2010specific persistence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24898","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T13:17:11Z","timestamp":1499865431000},"page":"76-83","source":"Crossref","is-referenced-by-count":6,"title":["Anal HPV 16 and 18 viral load: A comparison between HIV\u2010negative and \u2010positive MSM and association with persistence"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-392X","authenticated-orcid":false,"given":"Elske","family":"Marra","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Public Health Service of Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"King","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control National Institute for Public Health and the Environment (RIVM) Bilthoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elske","family":"van Logchem","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control National Institute for Public Health and the Environment (RIVM) Bilthoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"van der Weele","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control National Institute for Public Health and the Environment (RIVM) Bilthoven the Netherlands"},{"name":"Department of Pathology VU University Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie H.","family":"Mooij","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Public Health Service of Amsterdam Amsterdam the Netherlands"},{"name":"Centre for Infectious Disease Control National Institute for Public Health and the Environment (RIVM) Bilthoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titia","family":"Heijman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Public Health Service of Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J.L.M.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Pathology VU University Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique W.M.","family":"Verhagen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jan van Goyen Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne A. 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