{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:19:41Z","timestamp":1762867181593,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/50633\u20104"],"award-info":[{"award-number":["2011\/50633\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3\/NS4A domain and clinical features of 247 HCV mono or HCV\/HIV co\u2010infected patients. Fourteen samples (5.7%) harbored at least one resistance\u2010associated substitution (RAS). The following RASs were detected in NS3 region: T54S (6\u20102.4%), V55A (7\u20102.8%), and Q80R (2\u20100.8%). S122G occurred in 86.9% of HCV genotype 1b samples with either natural polymorphisms or RASs. Advanced liver fibrosis and HIV co\u2010infection were not related to NS3\/NS4A amino acid substitutions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24900","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T13:12:38Z","timestamp":1499865158000},"page":"2249-2254","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of clinical predictors of naturally occurring NS3\/NS4A protease polymorphism in genotype 1 hepatitis C virus mono and HIV co\u2010infected patients"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-7374","authenticated-orcid":false,"given":"Gaspar","family":"Lisboa Neto","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Laboratory of Virology\u2010 LIM 52. Institute of Tropical Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda M.","family":"Malta","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Gastroenterology and Hepatology \u2010 LIM\u201007. Institute of Tropical Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele S.","family":"Gomes\u2010Gouv\u00eaa","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Gastroenterology and Hepatology \u2010 LIM\u201007. Institute of Tropical Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline F.","family":"Noble","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Gastroenterology and Hepatology \u2010 LIM\u201007. Institute of Tropical Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-1987","authenticated-orcid":false,"given":"Camila M.","family":"Romano","sequence":"additional","affiliation":[{"name":"Laboratory of Virology\u2010 LIM 52. Institute of Tropical Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o R.","family":"Rebello Pinho","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Gastroenterology and Hepatology \u2010 LIM\u201007. Institute of Tropical Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Albert Einstein Medicina Diagn\u00f3stica Hospital Israelita Albert Einstein S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariliza H.","family":"Silva","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia e Treinamento em DST\/AIDS do Estado de S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Cl\u00ednicas de Especialidades S\u00e3o Bernardo do Campo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea G.B.","family":"Leite","sequence":"additional","affiliation":[{"name":"Centro Especializado em Sa\u00fade Caxias do Sul RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonora Z.","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Centro Especializado em Sa\u00fade Caxias do Sul RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flair J.","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Gastroenterology and Hepatology \u2010 LIM\u201007. Institute of Tropical Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Mendes\u2010Correa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Laboratory of Virology\u2010 LIM 52. Institute of Tropical Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26141"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12422"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2012.09.011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-010-0642-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762013000100002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02204-10"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(03)00070-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02004-12"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis761"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2015.06.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2606"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02776-15"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31780"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019562"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27934"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32830a989b"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2821"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:37:32Z","timestamp":1695991052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/jmv.24900"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24900","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}