{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T05:22:32Z","timestamp":1751347352400,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16fk0210201h0002"],"award-info":[{"award-number":["16fk0210201h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>In January 2012, Mongolia started a hepatitis A vaccination program, which has not yet been evaluated. The first occurrence of autochthonous acute hepatitis E in 2013, caused by genotype 4 hepatitis E virus (HEV), suggests the need for a routine study to monitor its prevalence. One hundred fifty\u2010four consecutive patients who were clinically diagnosed with acute hepatitis between 2014 and 2015 in Ulaanbaatar, Mongolia were studied. By serological and molecular testing followed by sequencing and phylogenetic analysis, only one patient (0.6%) was diagnosed with acute hepatitis A, caused by genotype IA hepatitis A virus (HAV), and 32 (20.8%) patients were diagnosed with acute hepatitis E, caused by genotype 1 HEV. The 32 HEV isolates obtained in this study shared 99.5\u2010100% nucleotide identity and were grouped into a cluster separated from those of subtypes 1a to 1f. Upon comparison of p\u2010distances over the entire genome, the distances between one representative HEV isolate (MNE15\u2010072) and 1a\u20101f strains were 0.071\u20100.137, while those between 1b and 1c were 0.062\u20100.070. In conclusion, the prevalence of acute hepatitis A has decreased in Mongolia since the start of the vaccination program, while the monophyletic genotype 1 HEV strain of a probably novel subtype has been prevalent.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24907","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T12:16:43Z","timestamp":1501849003000},"page":"84-92","source":"Crossref","is-referenced-by-count":9,"title":["Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis in Mongolia: The first report of the full genome sequence of a novel genotype 1 hepatitis E virus strain"],"prefix":"10.1002","volume":"90","author":[{"given":"Bira","family":"Tsatsralt\u2010Od","sequence":"first","affiliation":[{"name":"National Center for Communicable Diseases, Ministry of Health NCCD\u2010Campus Ulaanbaatar Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Putu Prathiwi","family":"Primadharsini","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity Jichi Medical University School of Medicine Shimotsuke Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity Jichi Medical University School of Medicine Shimotsuke Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity Jichi Medical University School of Medicine Shimotsuke Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity Jichi Medical University School of Medicine Shimotsuke Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity Jichi Medical University School of Medicine Shimotsuke Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suljid","family":"Jirintai","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Basic Veterinary Medicine Inner Mongolia Agricultural University College of Veterinary Medicine Hohhot Inner Mongolia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulmaa","family":"Nyamkhuu","sequence":"additional","affiliation":[{"name":"National Center for Communicable Diseases, Ministry of Health NCCD\u2010Campus Ulaanbaatar Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0827-0964","authenticated-orcid":false,"given":"Hiroaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity Jichi Medical University School of Medicine Shimotsuke Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.10.023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.61.1.50-59.1987"},{"key":"e_1_2_7_4_1","first-page":"855","volume-title":"Virus Taxonomy: Classification and Nomenclature of Viruses: Ninth Report of the International Committee on Taxonomy of Viruses","author":"Knowles NJ","year":"2012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81155-0"},{"key":"e_1_2_7_6_1","first-page":"550","volume-title":"Fields Virology","author":"Hollinger FB","year":"2013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24380"},{"key":"e_1_2_7_8_1","unstructured":"WHO. 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