{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:52:51Z","timestamp":1783666371503,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["30266"],"award-info":[{"award-number":["30266"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["28038"],"award-info":[{"award-number":["28038"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>In Iran, human papillomavirus (HPV) vaccination is not currently included in the national vaccination program and there are no comprehensive approaches to cervical screening program. Regional data on distribution of HPV types in women is important to predict the impact of current HPV vaccines. Although several studies on distribution of HPV types in cervical precancer and cancer have been conducted in Iran, in most of them HPV positive samples were subjected to specific\u2010primer genotyping (mainly 16 and 18), and leaving the other HPV genotypes almost undetermined. Therefore, the present study aimed to investigate the distribution of HPV types in cervical neoplasia from West and Northwest of Iran. A total of 112 women with atypia, cervical intraepithelial neoplasia, and invasive cervical cancer were included. A PCR assay was performed in all samples to detect the presence of the HPV genome using the GP5+\/6+ L1 consensus primer set. All HPV positive samples were subjected for sequencing. In overall, HPV prevalence was 20% in atypica, 44.5% in cervical intraepithelial neoplasia I, 92.3% in cervical intraepithelial neoplasia II\u2010III, and 98.2% in invasive cervical cancer. The most frequent HPV type was HPV 16 (79.2%), which was followed by HPV types 18, 6, and 33 at the frequencies of 6.5%, 5.1%, and 2.7%, respectively. The least HPV types were found to be 31, 45, 53, 58, and 66. In conclusion, this study shows that the current HPV vaccines could have great impact to reduce the burden of cervical cancer in Iran.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24908","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T09:12:40Z","timestamp":1502183560000},"page":"172-176","source":"Crossref","is-referenced-by-count":15,"title":["Type\u2010specific human papillomavirus prevalence in cervical intraepithelial neoplasia and cancer in Iran"],"prefix":"10.1002","volume":"90","author":[{"given":"Nasrin","family":"Heydari","sequence":"first","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahin A.","family":"Oskouee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Microbiology and Virology Tabriz University of Medical Sciences Infectious and Tropical Disease Research Center Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayebeh","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zabihollah","family":"Shoja","sequence":"additional","affiliation":[{"name":"Department of Virology Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidar A.","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasool","family":"Hamkar","sequence":"additional","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohreh","family":"Shahmahmoodi","sequence":"additional","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran"},{"name":"Tehran University of Medical Sciences Food Microbiology Research Center Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-8399","authenticated-orcid":false,"given":"Somayeh","family":"Jalilvand","sequence":"additional","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.089"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.06.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.11.046"},{"key":"e_1_2_7_5_1","unstructured":"International Agency for Research on Cancer. 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