{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:47:54Z","timestamp":1791157674892,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005349","name":"American Association of Colleges of Pharmacy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Obesity was identified as a risk factor for severe influenza during the 2009 influenza A(H1N1)pandemic, but evidence of this association has been mixed since. Post\u2010pandemic antiviral treatment guidelines may have increased antiviral treatment among obese individuals. A prospective study of adults hospitalized with laboratory\u2010confirmed influenza in Detroit, Michigan in 2011\u20102012 and 2012\u20102013 was conducted. Patient information was collected from interviews and medical chart abstraction. Obese (BMI\u2009\u2265\u200930) and non\u2010obese (BMI\u2009&lt;\u200930) participants were compared. Late antiviral treatment (&gt;2 days from symptom onset), obesity (30\u2009\u2264\u2009BMI\u2009&lt;\u200940), and morbid obesity (BMI\u2009\u2265\u200940) were evaluated as predictors of lower respiratory tract disease (LRD), ICU admission, and length of stay (LOS) using logistic regression and inverse probability weighted models. Forty\u2010eight participants were included in the study after exclusions and all patients received antiviral treatment. Participants who were obese were significantly more likely to have a cough and to take steroids than non\u2010obese participants, and had a shorter time from hospital admission to antiviral treatment (median time from admission to treatment of 0 days for obese patients and 1 day for non\u2010obese patients [<jats:italic>P<\/jats:italic>\u2009=\u20090.001]). In all models, late antiviral treatment was associated with increased odds of LRD (OR: 3.9 [1.1,15.9] in fully adjusted model). After adjustment for treatment timing, the odds of ICU admission (OR: 6.4 [0.8,58.2] to 7.9 [0.9, 87.1]) and LRD (OR: 3.3 [0.5, 23.5] to 4.0 [0.6, 35.0]) associated with morbid obesity increased. Obese individuals were treated with antivirals earlier than others. Late antiviral treatment was associated with severe influenza in the hospital.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24946","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T15:41:39Z","timestamp":1505144499000},"page":"212-218","source":"Crossref","is-referenced-by-count":27,"title":["The impact of obesity and timely antiviral administration on severe influenza outcomes among hospitalized adults"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4716-7468","authenticated-orcid":false,"given":"Hannah E.","family":"Segaloff","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Arshad","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus J.","family":"Zervos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Archer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith S.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine, University of Michigan Health System Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily T.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.87.12.1944"},{"key":"e_1_2_5_3_1","first-page":"1057","article-title":"Centers for disease control and prevention. estimates of deaths associated with seasonal influenza\u2010United States, 1976\u20132007","volume":"59","year":"2010","journal-title":"MMWR"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001053"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009694"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0588"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12156"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-2659.2012.00377.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir442"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2016.1201721"},{"key":"e_1_2_5_11_1","first-page":"1","article-title":"Antiviral agents for the treatment and chemoprophylaxis of influenza recommendations of the advisory committee on immunization practices (ACIP)","volume":"60","author":"Fiore A","year":"2011","journal-title":"MMWR"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg007"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr089"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/651083"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis636"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq144"},{"key":"e_1_2_5_17_1","unstructured":"CDC. NPAO Data Trends and Maps\u2014Location Summary\u2014Michigan Location Summary. Center for Disease Control and Prevention.https:\/\/nccd.cdc.gov\/NPAO_DTM\/LocationSummary.aspx?state=Michigan. Accessed September 23 2016."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12115"},{"key":"e_1_2_5_19_1","unstructured":"Centers for Disease Control and Prevention (CDC). Behavioral Risk Factor Surveillance System Survey Data. 2011.https:\/\/www.cdc.gov\/brfss\/questionnaires\/. Accessed May 11 2017."},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2215"},{"key":"e_1_2_5_21_1","unstructured":"Flu and People with Diabetes| Seasonal Influenza (Flu) | CDC. Center for Disease Control and Prevention.https:\/\/www.cdc.gov\/flu\/diabetes\/index.htm. Accessed July 21 2017."},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ733"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910444"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw745"},{"key":"e_1_2_5_25_1","unstructured":"QuickFacts US Census.https:\/\/www.census.gov\/quickfacts\/table\/INC110215\/2622000 00. Accessed February 27 2017."},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000364"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.35680\/2372-0247.1140","article-title":"Why do they do that?: Looking beyond typical reasons for non\u2010urgent ED use among Medicaid patients","volume":"3","author":"Sieck CJ","year":"2016","journal-title":"Patient Exp J"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:45:48Z","timestamp":1695980748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,25]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jmv.24946"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24946","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,25]]}}}