{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:57:17Z","timestamp":1792533437058,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR8706\/AGR\/36\/767\/2013"],"award-info":[{"award-number":["BT\/PR8706\/AGR\/36\/767\/2013"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>JEV infection in CNS leads to the JE neuroinflammation. Children and old age individual have been reported to be more prone to JEV infection. MicroRNAs are endogenous, small non\u2010coding RNAs, which regulate the gene expression. These are \u223c22 nucleotide long, conserved RNA sequence that binds at the 3\u2032UTR of a target mRNA and regulate the post\u2010transcriptional gene expression. The role of microRNAs has been reported in several diseases like cancer, viral infection, neuro\u2010degeneration, diabetes etc. In the present study, the human microglial cells were infected with JEV (JaOArS982). The control and infected samples were subject to microarray profiling for microRNA expression. The microarray profile yielded differentially expressed microRNAs from JEV infected samples. The microRNA gene targets, gene ontology, annotations, and pathways were identified through various bioinformatics tools. Additionally, the pathways were mostly found common to \u201cubiquitin mediated proteolysis,\u201d \u201ccytokine signaling,\u201d \u201cmaintenance of barrier function\/cell junctions,\u201d JAK\/STAT pathway\u201d \u201cToll\u2010like receptor signaling,\u201d \u201cWnt\u2010signaling,\u201d \u201cadhesion molecules,\u201d \u201capoptosis,\u201d \u201cendocytosis,\u201d \u201cvesicle mediated transport\u201d etc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24995","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T14:46:37Z","timestamp":1510929997000},"page":"648-654","source":"Crossref","is-referenced-by-count":18,"title":["Exploitation of microRNAs by Japanese Encephalitis virus in human microglial cells"],"prefix":"10.1002","volume":"90","author":[{"given":"Meghana","family":"Rastogi","sequence":"first","affiliation":[{"name":"Laboratory of Human Molecular Virology and Immunology Molecular Biology Unit, Faculty of Medicine Institute of Medical 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