{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:49Z","timestamp":1740104149393,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["14ZR1441600"],"award-info":[{"award-number":["14ZR1441600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302891\/81373861"],"award-info":[{"award-number":["81302891\/81373861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Spleen and kidney deficiency syndrome (SKD), a Traditional Chinese Medicine (TCM) syndrome, is the fundamental mechanisms of TCM. We aim to investigate the distribution of peripheral dendritic cells (DCs) in HBV patients with SKD or non\u2010SKD. Peripheral venous blood from patients with HBV infection and healthy volunteers was collected to extract PBMC, and flow cytometry assay was used to measure the distribution of DCs subsets, including myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). For the number of pDCs, it was higher in control group and non\u2010SKD group, compared with HBV infection group and SKD group, respectively. For the number of mDCs, it was higher in control group and the non\u2010SKD group compared to SKD group, while in control group it was higher than both HBeAg positive group and negative group. The number of pDCs in control group and chronic hepatitis B group were higher than HBVcarrier group, and it was higher in control group than both immune tolerance group and inactive group, while in immune clearance group it was higher than immune tolerance group and inactve group. The number of mDCs in control group and immune clearance group were higher than that of immune tolerance group. There was an obvious correlation between TCM syndromes and immune function in HBV infected patients, the number of pDCs and mDCs of the SKD group was lower than that in non\u2010SKD group. These results provide a new insight into scientific evidence that TCM probably be based.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24998","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T15:02:44Z","timestamp":1511449364000},"page":"706-711","source":"Crossref","is-referenced-by-count":0,"title":["Distribution of peripheral dendritic cells in patients with HBV infection or spleen and kidney deficiency"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7316-0257","authenticated-orcid":false,"given":"Weixia","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine Shanghai China"},{"name":"Department of Spleen and Stomach Disease Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Spleen and Stomach Disease,Shanghai Institute of Traditional Chinese Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaofei","family":"Niu","sequence":"additional","affiliation":[{"name":"Henan Institute of Traditional Chinese medicine Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Spleen and Stomach Disease,Shanghai Institute of Traditional Chinese Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjun","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Spleen and Stomach Disease Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China"},{"name":"Institute of Spleen and Stomach Disease,Shanghai Institute of Traditional Chinese Medicine Shanghai 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