{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:58:35Z","timestamp":1790517515787,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701632"],"award-info":[{"award-number":["81701632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex\u2010 and age\u2010matched children was included as a control. All subjects were genotyped for the most common single\u2010nucleotide polymorphisms (SNPs) in the PRR and the PRR signaling pathway using the SNPscan multiple SNP typing method. Binary logistic regression analysis revealed statistically significant differences in polymorphism of <jats:italic>RIG\u20101<\/jats:italic> between patients and controls (rs3739674 G vs C: OR\u2009=\u20091.502, 95%CI: 1.120\u20102.014; rs9695310 G vs C: OR\u2009=\u20091.782, 95%CI: 1.312\u20102.419). Polymorphisms of <jats:italic>RIG\u20101<\/jats:italic> rs3739674 (G vs C: OR\u2009=\u20092.047, 95%CI: 1.307\u20103.205) and <jats:italic>TLR3<\/jats:italic> rs5743305 (A vs T: OR\u2009=\u20090.346, 95%CI: 0.212\u20100.566) were found to be associated with disease severity. The results indicated that <jats:italic>RIG\u20101<\/jats:italic> (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71\u2010induced HFMD in Chinese children, whereas <jats:italic>RIG\u20101<\/jats:italic> rs3739674 and <jats:italic>TLR3<\/jats:italic> rs5743305 polymorphisms are associated with disease severity. These findings support an important role of innate immune mechanism in EV71 infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25000","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T03:52:47Z","timestamp":1513137167000},"page":"692-698","source":"Crossref","is-referenced-by-count":16,"title":["Association of gene polymorphisms of pattern\u2010recognition receptor signaling pathway with the risk and severity of hand, foot, and mouth disease caused by enterovirus 71 in Chinese Han population"],"prefix":"10.1002","volume":"90","author":[{"given":"Ya\u2010Ping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Li","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-8647","authenticated-orcid":false,"given":"Hui\u2010Ling","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China"},{"name":"Department of Infectious Diseases Xi'an Children's Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China"},{"name":"Department of Infectious Diseases Xi'an Children's Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-5711","authenticated-orcid":false,"given":"Shuang\u2010Suo","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411302"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v7122961"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.083001.084359"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.12.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.27902"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004127"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.06.045"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603082103"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-270"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100269"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.07.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.01.022"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.07.006"},{"key":"e_1_2_7_15_1","unstructured":"National Health and Family Planning Commission of the People's Republic of China. 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