{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:05:16Z","timestamp":1792782316284,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stiftung f\u00fcr Infektiologie beider Basel, Basel, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Acute gastroenteritis (GE) has a major impact on morbidity and mortality worldwide, yet comprehensive data regarding infectious agents including enteroviruses are scarce. We hypothesized that enteroviruses constitute a significant cause of acute GE. We analyzed 677 stool samples from 504 patients, which had been submitted for suspected infectious GE. 0.2\u2009mL of stool suspension was extracted using the Abbott\n                      <jats:italic>m<\/jats:italic>\n                      2000\n                      <jats:sub>sp<\/jats:sub>\n                      robot and analysed by multiplex nucleic acid testing (NAT) using the Luminex xTAG gastrointestinal pathogen panel (GPP) as well as by specific NATs detecting enteroviruses and polioviruses. Median age of the patients was 6.6 years (IQR 1.1\u201050.6; pediatric &lt;18 years). 292 of 677 (43%) samples were positive for at least one pathogen. Enterovirus was detected in 5.3% (36\/677) as sole pathogen (67%), and more frequently in children (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0054). Only rotavirus (18.6%) and norovirus (12.1%) were more frequent.\n                      <jats:italic>Clostridium difficile<\/jats:italic>\n                      and\n                      <jats:italic>Campylobacter jejuni<\/jats:italic>\n                      were detected in 5.5% and 2.2% of stools, respectively. Adenovirus,\n                      <jats:italic>E. coli<\/jats:italic>\n                      O157,\n                      <jats:italic>Salmonella<\/jats:italic>\n                      , Shiga toxin\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      (STEC),\n                      <jats:italic>Shigella, Giardia lamblia<\/jats:italic>\n                      ,\n                      <jats:italic>Cryptosporidium<\/jats:italic>\n                      , and\n                      <jats:italic>Entamoeba histolytica<\/jats:italic>\n                      were rare (&lt;1% of samples).\n                      <jats:italic>Vibrio cholerae<\/jats:italic>\n                      ,\n                      <jats:italic>Yersinia enterocolitica<\/jats:italic>\n                      , enterotoxigenic\n                      <jats:italic>E. coli<\/jats:italic>\n                      (ETEC) and poliovirus were not detected. Thus, non\u2010polio enteroviruses are the third most frequent pathogen in acute GE suggesting that enteroviruses may play an important role in GE even in developed, industrial health care settings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.25005","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T09:06:01Z","timestamp":1513155961000},"page":"685-691","source":"Crossref","is-referenced-by-count":21,"title":["Enterovirus detection in patients with acute gastroenteritis in Switzerland"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-8550","authenticated-orcid":false,"given":"Rainer","family":"Gosert","sequence":"first","affiliation":[{"name":"Division of Infection Diagnostics Department Biomedicine \u2212 Haus Petersplatz University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Heininger","sequence":"additional","affiliation":[{"name":"University of Basel Children's Hospital Pediatric Infectious Diseases and Vaccinology Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans H.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Division of Infection Diagnostics Department Biomedicine \u2212 Haus Petersplatz University of Basel Basel Switzerland"},{"name":"Infectious Diseases and Hospital Epidemiology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.Supplement_1.S41"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6553-9_2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.65"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01026-09"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.04.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00896-13"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2014.02.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0656-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041837"},{"key":"e_1_2_8_11_1","first-page":"545","article-title":"Giardia: overview and update","volume":"25","author":"Ortega YR","year":"1997","journal-title":"Oxford J"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011203"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(84)90084-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00702-09"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01637-14"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.074773-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01393-14"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24155"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.7.666"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0901.020175"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-1300-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/313901"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05079-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1825-9"},{"key":"e_1_2_8_25_1","first-page":"1822","article-title":"Rotavirus gastroenteritis in infants and children. 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