{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:03:18Z","timestamp":1777723398675,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["SR\/WOS\u2010A\/LS\u2010212\/2016(G)"],"award-info":[{"award-number":["SR\/WOS\u2010A\/LS\u2010212\/2016(G)"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Human leucocyte antigen (HLA) represents one of the most highly polymorphic systems which plays a central role in the immune response. Genetic polymorphism of HLA in influenza A(H1N1)pdm09 infected population may be an important factor in disease progression and severity that needs further probing. In this study, a total of 110 Influenza like illness patients were recruited from the population of Assam, Northeast India, from which 35 cases infected by A(H1N1)pdm09 viruses and 35 controls were typed for HLA\u2010A, B and DRB1 locus by PCR\u2010SSP method. A total of seven alleles of HLA\u2010A, 16 alleles of HLA\u2010B, and 11 alleles of HLA\u2010DRB1 locus were identified. The most common alleles within each locus in cases were HLA\u2010A*11 (85.71%,<jats:italic>P<\/jats:italic>\u2009=\u20090.046), HLA\u2010B*35 (25%,<jats:italic>P\u2009<\/jats:italic>=\u20090.0001), and HLA\u2010DRB1*15 (49.35%, \u2009<jats:italic>P\u2009<\/jats:italic>=\u20090.133) as compared to the controls, HLA\u2010A*11 (40.82%), HLA\u2010B*35 (0.00%), and HLA\u2010DRB1*15 (67.53%). The frequency of HLA\u2010A*11 and HLA\u2010B*35 were significantly higher in cases as compared to the controls. In DRB1 locus, HLA\u2010DRB1*10 was significantly higher in cases (20.78%,<jats:italic>P<\/jats:italic>\u2009=\u20090.005) than that of controls (0.00%). Whereas, HLA\u2010DRB1*15 showed a higher frequency in controls than in cases. In addition, HLA\u2010DRB3*01 (<jats:italic>P<\/jats:italic>\u2009=\u20090.053), DRB4*01 (<jats:italic>P<\/jats:italic>\u2009=\u20091.000), and DRB5*01(<jats:italic>P<\/jats:italic>\u2009=\u20090.591) were also identified along with HLA\u2010DRB1 haplotype. From this preliminary study, it is suspected that there may be a role of HLA\u2010A*11, HLA\u2010B*35 and HLA\u2010DRB1*10 in conferring susceptibility to influenza A(H1N1)pdm09 infection in the study population. A larger extended study on HLA polymorphism may explain the association between HLA and influenza A(H1N1)pdm09 infection and provide insights for HLA restricted peptide based vaccines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25018","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T01:36:29Z","timestamp":1515548189000},"page":"854-860","source":"Crossref","is-referenced-by-count":51,"title":["Polymorphism of HLA class I and class II alleles in influenza A(H1N1)pdm09 virus infected population of Assam, Northeast India"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0819-2786","authenticated-orcid":false,"given":"Mousumi","family":"Dutta","sequence":"first","affiliation":[{"name":"Virology Division ICMR\u2010Regional Medical Research Centre N.E. Region Dibrugarh Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-3303","authenticated-orcid":false,"given":"Prafulla","family":"Dutta","sequence":"additional","affiliation":[{"name":"Virology Division ICMR\u2010Regional Medical Research Centre N.E. Region Dibrugarh Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash","family":"Medhi","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Technology Institute of Science and Technology Gauhati University Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6922-4198","authenticated-orcid":false,"given":"Biswajyoti","family":"Borkakoty","sequence":"additional","affiliation":[{"name":"Virology Division ICMR\u2010Regional Medical Research Centre N.E. Region Dibrugarh Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipankar","family":"Biswas","sequence":"additional","affiliation":[{"name":"Virology Division ICMR\u2010Regional Medical Research Centre N.E. Region Dibrugarh Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Centers for Disease Control and Prevention (CDC)2017.https:\/\/www.cdc.gov\/flu\/avianflu\/influenza\u2010a\u2010virus\u2010subtypes.htm."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008754"},{"key":"e_1_2_8_4_1","first-page":"28","article-title":"A comparative study of HLA\u2010A and HLA\u2010\u0412 antigens and haplotype distribution among donors of hematopoietic stem cells from Russian and German regions","volume":"1","author":"Bubnova LN","year":"2008","journal-title":"Cell Ther and Transplant"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000399"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/44853"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90134-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2008.00765.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00048-08"},{"key":"e_1_2_8_10_1","unstructured":"World health organization. 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