{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:00:32Z","timestamp":1776128432642,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Serum levels of alpha\u2010fetoprotein (AFP) were reported to increase in patients with significant or advanced hepatic fibrosis. Combination of non\u2010invasive tests decreases the use of liver biopsy in large proportion of chronic HCV patients. The aim of the study was to compare and combine AFP with commonly used non\u2010invasive fibrosis tests in novel scores for prediction of different stages of hepatic fibrosis. Six hundred and fifty two treatment na\u00efve chronic hepatitis C patients were enrolled. Demographic data, basic pre\u2010treatment laboratory tests including complete blood count (CBC), liver biochemical profile and renal functions test, international normalized ratio (INR) in addition to AFP, liver stiffness measurement (LSM) by Fibroscan and liver biopsies were retrospectively analyzed. AST to Platelet Ratio Index (APRI) and FIB\u20104 scores were calculated. Different predictive models using multivariate logistic regression analysis were generated and presented in equations (scores) composed of a combination of AFP, LSM plus FIB\u20104\/APRI scores. AFP was correlating significantly with LSM, FIB\u20104, and APRI scores. Areas under receiver operating characteristic curves (AUROCs) for predicting significant hepatic fibrosis, advanced hepatic fibrosis, and cirrhosis were 0.897, 0.931, and 0.955, respectively, for equations (scores) containing AFP, LSM, and FIB\u20104. AUROCs for predicting significant hepatic fibrosis, advanced hepatic fibrosis and cirrhosis were 0.897, 0.929, and 0.959, respectively, for equations (scores) containing AFP, LSM, and APRI. The study shows that combining AFP to serum biomarkers and LSM increases their diagnostic performance for prediction of different stages of liver fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25026","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T04:13:49Z","timestamp":1515557629000},"page":"1080-1086","source":"Crossref","is-referenced-by-count":21,"title":["Novel scores combining AFP with non\u2010invasive markers for prediction of liver fibrosis in chronic hepatitis C patients"],"prefix":"10.1002","volume":"90","author":[{"given":"Mohamed","family":"Gamil","sequence":"first","affiliation":[{"name":"National Hepatology and Tropical Medicine Research institute Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Alboraie","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-2509","authenticated-orcid":false,"given":"Mohammad","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Asem","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Mohey","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahaa","family":"Abbas","sequence":"additional","affiliation":[{"name":"Military Medical Academy Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7934-891X","authenticated-orcid":false,"given":"Mai","family":"Mehrez","sequence":"additional","affiliation":[{"name":"National Hepatology and Tropical Medicine Research institute Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal","family":"Esmat","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.15.10.814"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1016\/S0021-9258(18)89178-5","article-title":"The human alpha\u2010fetoprotein gene. 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