{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:32:21Z","timestamp":1763037141384,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017R1C1B5017839"],"award-info":[{"award-number":["NRF\u20102017R1C1B5017839"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Infection caused by <jats:italic>Varicella zoster virus<\/jats:italic> (VZV) is a common etiology of acute peripheral facial palsy (APFP). We aimed to assess the clinical significance of detecting VZV DNA from the saliva of patients with APFP. Saliva collected from 36 patients with unilateral APFP at initial visit was analyzed to detect VZV DNA by polymerase chain reaction. The House\u2010Brackmann (HB) scale was used to evaluate FP severity on admission day, at week 2, and at weeks 10\u201012 after start of treatment. Among the 28 patients without rash, VZV DNA was detected in 3 patients (10.7%); 6 of 8 patients (75.0%) with rash showed VZV DNA (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). VZV DNA\u2010positive patients had worse hearing than VZV DNA\u2010negative patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A significantly higher proportion of VZV DNA\u2010negative patients (96.3%) showed complete recovery than VZV DNA\u2010positive patients (55.6%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.006). In conclusion, VZV DNA\u2010positive patients had worse hearing and incomplete recovery compared to VZV DNA\u2010negative patients, irrespective of the presence of rash. Tests for the detection of VZV DNA in saliva may be helpful for early differential diagnosis and choosing an appropriate medical treatment of APFP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25030","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T17:14:51Z","timestamp":1515604491000},"page":"959-964","source":"Crossref","is-referenced-by-count":8,"title":["Characteristics of patients with acute peripheral facial palsy showing <i>Varicella zoster virus<\/i> DNA in saliva"],"prefix":"10.1002","volume":"90","author":[{"given":"Dong Sik","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Eulji University Hospital Eulji University Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Eulji University Hospital Eulji University Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Ae","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Medical Science Chungnam National University Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9590-3477","authenticated-orcid":false,"given":"Ho Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Eulji University Hospital Eulji University Daejeon Republic of 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