{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:43:39Z","timestamp":1787316219064,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hospital Program For Clinical Research-PHRC","award":["AOI 203"],"award-info":[{"award-number":["AOI 203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      To assess risk factors of recurrent bronchial obstruction and allergic sensitization 3 years after an episode of acute bronchiolitis, whether after ambulatory care treatment or hospitalization. A monocentric prospective longitudinal study including infants aged under 1 year with acute bronchiolitis was performed, with clinical (severity score), biological (serum Krebs von den Lungen 6 antigen), and viral (14 virus by naso\u2010pharyngeal suction detection) assessments. Follow\u2010up included a quaterly telephone interview, and a final clinical examination at 3 years. Biological markers of atopy were also measured in peripheral blood, including specific IgEs towards aero\u2010 and food allergens. Complete data were available for 154 children. 46.8% of them had recurrent wheezing (RW). No difference was found according to initial severity, care at home or in the hospital, respiratory virus involved, or existence of co\u2010infection. A familial history of atopy was identified as a risk factor for recurrent bronchial obstruction (60% for RW infants versus 39%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02), as living in an apartment (35% versus 15%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). 18.6% of the infants were sensitized, with 48.1% of them sensitized to aeroallergens and 81.5% to food allergens. Multivariate analysis confirmed that a familial history of atopy (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) and initial co\u2010infection RSV\u2010hRV (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) were correlated with the risk of sensitization to aeroallergens at 3 years. Familial history of atopy and RSV\u2010hRV co\u2010infection are risk factors for recurrent bronchial obstruction and sensitization.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.25037","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T04:56:43Z","timestamp":1517288203000},"page":"867-872","source":"Crossref","is-referenced-by-count":20,"title":["RSV\u2010hRV co\u2010infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis"],"prefix":"10.1002","volume":"90","author":[{"given":"Flore","family":"Amat","sequence":"first","affiliation":[{"name":"Department of Allergology Centre de l'Asthme et des Allergies H\u00f4pital d'Enfants Armand Trousseau Assistance Publique\u2010H\u00f4pitaux de Paris UPMC Univ Paris 06 Sorbonne Universit\u00e9s; Equipe EPAR Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique INSERM Facult\u00e9 de M\u00e9decine Saint\u2010Antoine Paris Paris France"},{"name":"Pediatric Emergency Department CHU\u2010 Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Plantard","sequence":"additional","affiliation":[{"name":"Department of Immunology CHU\u2010Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mulliez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics CHU\u2010Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Petit","sequence":"additional","affiliation":[{"name":"Investigation Clinical Center CHU\u2010Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5180-9916","authenticated-orcid":false,"given":"Emmanuelle","family":"Rochette","sequence":"additional","affiliation":[{"name":"Investigation Clinical Center CHU\u2010Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Verdan","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department CHU\u2010 Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Henquell","sequence":"additional","affiliation":[{"name":"Laboratory of Virology CHU\u2010Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Labb\u00e9","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department CHU\u2010 Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Christine","family":"Heraud","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department CHU\u2010 Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Evrard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics CHU\u2010Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Labb\u00e9","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department CHU\u2010 Clermont\u2010Ferrand Clermont Ferrand France"},{"name":"Laboratory of Virology CHU\u2010Clermont\u2010Ferrand Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413456"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308723"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00188210"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339811795589423"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12318"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.77"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01283.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000879"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23850"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9807019"},{"key":"e_1_2_6_12_1","first-page":"1774","article-title":"American academy of pediatrics subcommittee on diagnosis and management of bronchiolitis. 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