{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:29:15Z","timestamp":1761514155255,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Hepatitis E virus (HEV) is a feco\u2010orally transmitted pathogen and one of the most common cause of acute hepatitis worldwide. Recent studies in developed countries suggested that a direct human\u2010to\u2010human contact such as for sexually transmitted diseases may play a significant role in the HEV spread. The aim of this study was to investigate the seroprevalence of HEV and HAV in a group of MSM, including subjects HIV, and Treponema infected, in Milan, Italy. The overall anti HEV IgG seroprevalence in MSM was 10.2% (65\/636), instead in the control group the detection rate was 5.2% (15\/288) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); the anti HAV seroprevalence was 42.8% in MSM, when in the control group the positivity rate was 29.2% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The rate of coinfection HEV\/HAV was 14.6% in MSM and 1% in control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In the future, sexual history, HIV status, and STI risk might address specific investigations to prevent spread of pathogens such HEV in MSM, before becoming a substantial public health problem like for HAV outbreaks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25052","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T11:33:19Z","timestamp":1518694399000},"page":"1323-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["HEV and HAV seroprevalence in men that have sex with men (MSM): An update from Milan, Italy"],"prefix":"10.1002","volume":"90","author":[{"given":"Letizia","family":"Greco","sequence":"first","affiliation":[{"name":"Virology Unit Fondazione Ca\u2019 Granda IRCCS Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara C.","family":"Uceda Renteria","sequence":"additional","affiliation":[{"name":"Virology Unit 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