{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:20:21Z","timestamp":1761920421497,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2015HM069"],"award-info":[{"award-number":["ZR2015HM069"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571995"],"award-info":[{"award-number":["81571995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Epstein\u2010Barr virus (EBV) is etiologically linked to nasopharyngeal carcinoma, lymphoma, and gastric carcinoma. The aim of this study was to assess the association of TM2 domain containing 3 (TM2D3) and fibroblast growth factor receptor 2 (FGFR2) SNPs rs675436 and rs755793 with susceptibility to EBV\u2010associated tumors in Chinese Han population. Genomic DNA of 415 patients with cancer and 99 healthy controls was assessed using a MALDI\u2010TOF mass spectrometer, and was genotyped in EBV\u2010associated\/\u2010negative gastric cancer (EBVa\/nGC), EBV\u2010associated\/\u2010negative nasopharyngeal carcinoma (EBVa\/nNPC), EBV\u2010associated\/\u2010negative lymphoma (EBVa\/nL), and normal controls (NC). The chi\u2010squared (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>) test or Fisher's exact test was used to compare all results and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant. The results showed that the G\u2010allele of rs675436 was less prevalent in EBVaGC as than in the other groups, while the T\u2010allele was more prevalent in EBVaGC (EBVaGC vs EBVnGC: <jats:italic>P<\/jats:italic>\u2009=\u20090.005, OR\u2009=\u200910.522, 95%CI\u2009=\u20091.377\u201080.376; EBVaGC vs NC: <jats:italic>P<\/jats:italic>\u2009=\u20090.005, OR\u2009=\u200910.637, 95%CI\u2009=\u20091.392\u201081.263). Interestingly, the distribution of the genotype and allele frequencies of rs675436 was significantly different between EBVaGC and EBVaNPC. Neither the genotype nor allele frequency of rs755793 was statistically different between any two groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). These findings indicated that the TT genotype and T allele frequencies of rs675436 were associated with an increased risk of EBVaGC, while allele A or G of rs755793 had no effect on the occurrence of EBV\u2010associated tumors in Chinese Han population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25057","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T11:27:06Z","timestamp":1518694026000},"page":"1128-1133","source":"Crossref","is-referenced-by-count":2,"title":["TM2D3 rs675436 or FGFR2 rs755793 polymorphisms and susceptibility to Epstein\u2010Barr virus\u2010associated tumors in Chinese Han population"],"prefix":"10.1002","volume":"90","author":[{"given":"Qianqian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology Qingdao University Medical College Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Qingdao University Medical College Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Qingdao University Medical College Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Qingdao University Medical College Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-5958","authenticated-orcid":false,"given":"Bing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Qingdao University Medical College Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199504000-00020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.12.030"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4448"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-015-3592-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044579X0200086X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.04.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0534"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.08.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006327"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060108"},{"key":"e_1_2_7_14_1","first-page":"1854","article-title":"FGFR2 gene polymorphisms are associated with breast cancer risk in the Han Chinese population","volume":"5","author":"Xia P","year":"2015","journal-title":"Am J Cancer Res"},{"key":"e_1_2_7_15_1","first-page":"94","article-title":"Evaluation of FGFR2 gene polymorphism in women with breast cancer","volume":"61","author":"Salehi Z","year":"2015","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010grand)"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23862"},{"key":"e_1_2_7_17_1","first-page":"875","article-title":"Co\u2010expression of keratinocyte growth factor and K\u2010sam is an independent prognostic factor in gastric carcinoma","volume":"21","author":"Toyokawa T","year":"2009","journal-title":"Oncol Rep"},{"key":"e_1_2_7_18_1","first-page":"3541","article-title":"Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers","volume":"61","author":"Jang J H","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.96"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117089"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3898"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/503849"},{"key":"e_1_2_7_23_1","first-page":"1461","article-title":"Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma. 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