{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:20:18Z","timestamp":1778599218152,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Assessment of hepatic fibrosis in chronic hepatitis C virus patients by liver biopsy is not widely accepted despite its accuracy, being invasive, carrying complications, and adding cost. This paved the way to development and use of non\u2010invasive markers of fibrosis in diagnosis of hepatic fibrosis. We aimed at evaluating the efficiency of Fib\u20104, Egy\u2010score, Aspartate\u2010to\u2010platelet ratio index (APRI), and G\u00f6teborg University Cirrhosis Index (GUCI) in comparison to liver biopsy, in the assessment of hepatic fibrosis in chronic hepatitis C patients. This was a cross sectional study including 200 chronic HCV patients were divided into two groups according to stage of fibrosis (Metavir score) into non\u2010significant fibrosis (&lt;F2) and significant fibrosis (\u2265F2). Reference needle liver biopsy was compared to Fib\u20104, Egyscore, APRI, and GUCI. Older age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and higher BMI (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) were significantly related to significant fibrosis and positively correlated with fibrosis progression (<jats:italic>r<\/jats:italic>\u2009=\u20090.361, <jats:italic>P<\/jats:italic>\u2009=\u20090.000, and <jats:italic>r<\/jats:italic>\u2009=\u20090.165, <jats:italic>P<\/jats:italic>\u2009=\u20090.019 respectively). Fib\u20104 &gt;1.27, APRI &gt;0.48, Egy\u2010score &gt;0.73, and GUCI &gt;0.57 significantly predict significant fibrosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Fib\u20104 carries the best performance and significant reliability with AUROC 0.783, sensitivity 74%, specificity 69%, PPV 0.55, and NPV 0.86. The addition of BMI to Fib\u20104 improved the significant fibrosis AUROC curve performance but did not reach statistical significant improvement. We concluded that age and BMI are good predictors of hepatic fibrosis. Fib\u20104 (&gt;1.27) is the best method of prediction of significant fibrosis compared to Egy\u2010score, APRI, and GUCI. Addition of BMI to Fib\u20104 did not improve diagnostic value of Fib\u20104.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25064","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T11:56:44Z","timestamp":1519473404000},"page":"1106-1111","source":"Crossref","is-referenced-by-count":15,"title":["Comparing the efficiency of Fib\u20104, Egy\u2010score, APRI, and GUCI in liver fibrosis staging in Egyptians with chronic hepatitis C"],"prefix":"10.1002","volume":"90","author":[{"given":"Ahmed","family":"Cordie","sequence":"first","affiliation":[{"name":"Endemic Medicine Department and Hepatology Unit Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Salama","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department and Hepatology Unit Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"El\u2010Sharkawy","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-8978","authenticated-orcid":false,"given":"Saeed M.","family":"El\u2010Nahaas","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department and Hepatology Unit Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Khairy","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department and Hepatology Unit Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department and Hepatology Unit Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6001-8793","authenticated-orcid":false,"given":"Mohamed","family":"Hassany","sequence":"additional","affiliation":[{"name":"National Hepatology and Tropical Medicine Research Institute Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal","family":"Esmat","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department and Hepatology Unit Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13316"},{"key":"e_1_2_8_4_1","unstructured":"Ministry of Health Egypt El\u2010Zanaty and Associates Egypt and ICF International. 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