{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:30Z","timestamp":1740104130517,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30700189"],"award-info":[{"award-number":["30700189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["QN2008\u201021"],"award-info":[{"award-number":["QN2008\u201021"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>The first three cases of confirmed infection with the virus in China were documented between May 10 and May 15, 2009. Although the clinical characteristics of the H1N1 pneumonia were described in clinical reports, the therapy has few been described. Therefore, we report our experiences of 53 cases of the H1N1 pneumonia with treatment. We describe clinical characteristic of 53 patients who were hospitalized for laboratory\u2010confirmed H1N1 pneumonia at the 2nd Clinical College of Harbin Medical University. In addition, we measure the role of corticosteroid, mechanical ventilation, and non\u2010corticosteroid antiviral therapy in the management of pneumonia patients with novel H1N1 infection. Real\u2010time reverse\u2010transcriptase\u2010polymerase chain (RT\u2010PCR) testing was used to confirm infection. The outcome of therapy was compared in scores of PaO<jats:sub>2<\/jats:sub> and CT. The data was statistical analyzed by the Shapiro\u2010Wilk, anova, Student\u2010Newman\u2010Keuls Test, and Kruskal\u2010Wallis Test. The most common symptoms were dyspnea. In moderate ill patients, the changes in the increased PaO<jats:sub>2<\/jats:sub> were lower in the non\u2010corticosteroid antiviral therapy group than in the combination of corticosteroid and non\u2010corticosteroid antiviral therapy after 5 days\u2019 therapy. The therapy protocol of non\u2010corticosteriod\u2009+\u2009mechanical ventilation played important role in the recovery of severe ill patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25077","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:07:58Z","timestamp":1521990478000},"page":"1675-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Corticosteroid therapy in pneumonia from swine\u2010origin influenza A (H1N1) in China"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-4599","authenticated-orcid":false,"given":"Yanyun","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongju","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904252"},{"key":"e_1_2_7_3_1","first-page":"470","article-title":"Swine\u2010origin influenza A (H1N1) virus infections in a school\u2014New York City, April 2009","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_4_1","first-page":"400","article-title":"Swine influenza A (H1N1) infection in two children\u2013Southern California, March\u2010April 2009","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_5_1","first-page":"433","article-title":"Update: drug susceptibility of swine\u2010origin influenza A (H1N1) viruses, April 2009","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903812"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08182"},{"key":"e_1_2_7_8_1","first-page":"467","article-title":"Outbreak of swine\u2010origin influenza A (H1N1) virus infection\u2014Mexico, March\u2010April 2009","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_9_1","unstructured":"Centers for Disease Control and Prevention (U.S.). Interim guidance for correctional and detention facilities on novel influenza A (H1N1) virus; 2009. Available online athttps:\/\/www.cdc.gov\/h1n1flu\/guidance\/correctional_facilities.htm. Accessed May 24 2009."},{"key":"e_1_2_7_10_1","first-page":"431","article-title":"Update: infections with a swine\u2010origin influenza A (H1N1) virus\u2013United States and other countries, April 28, 2009","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_11_1","unstructured":"World Health Organization (2009). Global alert and response: pandemic (H1N1) 2009. Available online athttp:\/\/www.who.int\/csr\/disease\/swineflu\/en\/index.html. 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Available online athttp:\/\/www.who.int\/csr\/resources\/publications\/swineflu\/realtimeptpcr\/en\/index.htmlAccessed October 6 2009."},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","DOI":"10.2807\/ese.14.17.19193-en","article-title":"The origin of the recent swine influenza A(H1N1) virus infecting humans","volume":"14","author":"Trifonov V","year":"2009","journal-title":"Euro Surveill"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.189.3.8080483"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904252"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/591708"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906612"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.25077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T04:34:59Z","timestamp":1694320499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/jmv.25077"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25077","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2018,6,13]]},"assertion":[{"value":"2017-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}