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However, the studies focused on naturally occurring, pre\u2010existing DRMs among co\u2010infected patients in China are limited. To investigate DRMs prevalence in treatment\u2010na\u00efve human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) mono\u2010 and co\u2010infected patients in China, a total of 570 patients were recruited for this study. DRMs sequences were amplified and successfully sequenced in 481 of these patients, who were grouped into three cohorts: (i) The HBV cohort included 100 HIV\/HBV co\u2010infected and 110 HBV mono\u2010infected patients who were sequenced for HBV; (ii) The HCV cohort included 91 patients who were HIV\/HCV co\u2010infected and 72 who were HCV mono\u2010infected for HCV sequencing; and (iii) The HIV cohort included 39 HIV mono\u2010infected, 22 HIV\/HCV, and 47 HIV\/HBV co\u2010infected patients for HIV sequencing. Next\u2010generation sequencing and Sanger sequencing were used in this study. The results showed that in the HCV cohort, HCV genotypes 6a (<jats:italic>P<\/jats:italic> &lt; 0.001) and 3b (<jats:italic>P<\/jats:italic> = 0.004) were more prevalent in HIV\/HCV co\u2010infected patients, however, the prevalence of HBV and HIV genotypes were similar within the HBV and HIV cohorts. HBV DRMs prevalence was significantly higher in HIV\/HBV co\u2010infected than HBV mono\u2010infected patients (8.0% vs 0.9%, <jats:italic>P<\/jats:italic> = 0.015), whereas HCV and HIV DRMs did not differ within the HCV and HIV cohort (<jats:italic>P<\/jats:italic> &gt; 0.05). This study revealed that HBV DRMs were more prevalent in HIV\/HBV co\u2010infected patients in China, while DRMs in HCV and HIV patients did not differ. Further dynamic surveillance of DRMs may be needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25078","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T03:00:25Z","timestamp":1521946825000},"page":"1246-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Naturally occurring antiviral drug resistance in HIV patients who are mono\u2010infected or co\u2010infected with HBV or HCV in China"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-9101","authenticated-orcid":false,"given":"Haohui","family":"Deng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Department of Infectious Diseases, Guangzhou Eight People's Hospital Guangzhou 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