{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:52:31Z","timestamp":1790855551675,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1204811"],"award-info":[{"award-number":["U1204811"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Indoleamine\u20102,3\u2010dioxygenase (IDO) is an enzyme that catalyzes tryptophan to kynurenine and studies have revealed that IDO play a vital role in regulation of liver immunity and inflammation activities. This study investigated the association between plasma IDO and disease severity and the possible marker role of IDO in the inflammatory process of hepatitis C. In this study, 80 individuals with HCV infection were retrospectively selected. Plasma levels of IDO, IL\u201010, and TGF\u2010\u03b2 were assayed by ELISA. Clinical characteristics of patients, including the levels of ALT, AST, and total bilirubin (TBil) were collected from clinical databases. HCV\u2010related liver cirrhosis (HC\u2010Cirr) and HCV\u2010related Hepatocellular carcinoma (HCV\u2010HCC) had significantly high plasma levels of IDO compared to other patient groups and healthy controls. Plasma IL\u201010 level were significantly greater in all chronic liver disease groups and with respect to TGF\u2010\u03b2, the level was high in all the selected patients with HCV infection compare with controls. Moreover, HCV\u2010HCC patients showed highest values for both IL\u201010 and TGF\u2010\u03b2, with significant difference compared with other groups. In addition, plasma IDO was positively correlated with TGF\u2010\u03b2 among all patients with HCV infection (<jats:italic>r<\/jats:italic>\u2009=\u20090.4509, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), with IL\u201010 in CHC patients (<jats:italic>r<\/jats:italic>\u2009=\u20090.4787, <jats:italic>P<\/jats:italic>\u2009=\u20090.0047), with TBil in HCV\u2010Cirr patients (<jats:italic>r<\/jats:italic>\u2009=\u20090.4671; <jats:italic>P<\/jats:italic>\u2009=\u20090.0093). High level of IDO and TGF\u2010\u03b2 is associated with hepatocyte necrosis and intrahepatic inflammation, and may be used as an index of disease progression for patients with chronic HCV infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25083","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T15:55:01Z","timestamp":1522770901000},"page":"265-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The role of IDO, IL\u201010, and TGF\u2010\u03b2 in the HCV\u2010associated chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0408-4873","authenticated-orcid":false,"given":"Ruonan","family":"Yang","sequence":"first","affiliation":[{"name":"Clinical Laboratory First Affiliated Hospital of Zhengzhou University Key Laboratory of Laboratory Medicine of Henan Province Zhengzhou Henan P.R. 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