{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:35:14Z","timestamp":1787949314651,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Minist\u00e9rio da Sa\u00fade, Fundo Nacional de Sa\u00fade, Departamento de IST\/AIDS e Hepatites Virais","award":["25000.214350\/2012-24"],"award-info":[{"award-number":["25000.214350\/2012-24"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti\u2010Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive individuals (55.4% men; mean age 43.1\u2009\u00b1\u200913.4 years) from 24 of 26 Brazilian states were tested for the presence of anti\u2010Delta antibodies using a commercial immunoassay. Anti\u2010Delta antibodies were detected in 40 samples (3.2%; 52.5% female; mean age of 38.1\u2009\u00b1\u200913.8 years). Age less than 20 years was significantly associated with anti\u2010HDV positivity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The distribution of anti\u2010Delta differed markedly in the diverse regions of the country. The highest prevalence of anti\u2010HDV was found in the North (8.5%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), followed by Central West (2.5%), Southeast (1.7%), Northeast (0.8%), and South (0.0%). Anti\u2010Delta antibodies were detected in 12 states, but more than 60% of the positive cases were observed in two states, Amazonas and Acre, located in the western portion of the Amazon region. The overall HDV prevalence of 3.2% emphasizes that HDV is far from being a disease under control in Brazil. Despite the low HDV prevalence in non\u2010endemic regions, this infection persists as a major concern in two states (Acre and Amazonas) in the north of the country, indicating that a continuous epidemiological surveillance program should be implemented in all Brazilian regions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25196","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:39:20Z","timestamp":1523939960000},"page":"1358-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Hepatitis D infection in Brazil: Prevalence and geographical distribution of anti\u2010Delta antibody"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-6309","authenticated-orcid":false,"given":"Barbara V.","family":"Lago","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Hepatites Virais Instituto Oswaldo Cruz, FIOCRUZ Rio de Janeiro, RJ Brazil"},{"name":"Instituto de Tecnologia em Imunobiol\u00f3gicos (Bio\u2010Manguinhos) FIOCRUZ Rio de Janeiro, RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4561-4332","authenticated-orcid":false,"given":"Francisco C. 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