{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:37Z","timestamp":1740104137615,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T00:00:00Z","timestamp":1527206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>A newly developed dengue virus vaccine (chimeric yellow fever virus\u2010tetravalent dengue vaccine [CYD\u2010TDV]) has recently been licensed for clinical use. The World Health Organization recommends vaccination for populations with seroprevalence of at least 70% to maximize public health impact. This study aimed to delineate the seroprevalence of dengue infection in Hong Kong. A total of 105\u2009972 serum samples submitted for clinical testing during the period 2013\u20102015 were age\u2010stratified and sex\u2010stratified. For each year of collection, 25 samples were randomly selected from each age\u2010sex group. Altogether, 2100 samples were tested for the dengue immunoglobulin G (IgG) antibody using a non\u2010type\u2013specific ELISA kit. The overall dengue IgG\u2010positive rate was 4.6% and showed no significant change over the 3 years. The positive rate was not associated with sex, but a steep rise in seroprevalence for persons above 65 years (32.7%) was observed. The low dengue seroprevalence in Hong Kong does not support implementation of a national immunization program. Majority of the population in Hong Kong are susceptible to dengue infection, and a substantial proportion of persons older than 65 years could acquire secondary infection and are prone to develop severe dengue.<\/jats:p>","DOI":"10.1002\/jmv.25216","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T14:20:29Z","timestamp":1525270829000},"page":"1427-1430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age\u2010specific seroprevalence of dengue infection in Hong Kong"],"prefix":"10.1002","volume":"90","author":[{"given":"Polly","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology Queen Elizabeth Hospital  Kowloon Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apple C.M.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zigui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin C.W.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin Ho","family":"Sze","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-4608","authenticated-orcid":false,"given":"Paul K.S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"},{"name":"Faculty of Medicine Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_1_2_1","DOI":"10.2147\/CLEP.S34440"},{"volume-title":"Global Strategy for Dengue Prevention and Control, 2012\u20132020","year":"2012","author":"World Health Organization (WHO)","key":"e_1_2_5_1_3_1"},{"key":"e_1_2_5_1_4_1","first-page":"349","article-title":"Dengue vaccine: WHO position paper\u2014July 2016","volume":"30","author":"World Health Organization (WHO)","year":"2016","journal-title":"Wkly Epidemiol Rec"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_5_1","DOI":"10.1099\/vir.0.015420-0"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_6_1","DOI":"10.1007\/s00705-013-1645-3"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_7_1","DOI":"10.1056\/NEJMoa1411037"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_8_1","DOI":"10.1016\/S0140-6736(14)61060-6"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_9_1","DOI":"10.2471\/BLT.15.168765"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_10_1","DOI":"10.1016\/S0140-6736(14)61142-9"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_11_1","DOI":"10.1056\/NEJMe1413146"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_12_1","DOI":"10.1586\/14760584.2016.1143366"},{"doi-asserted-by":"publisher","key":"e_1_2_5_1_13_1","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E"},{"key":"e_1_2_5_1_14_1","first-page":"95","article-title":"Dengue vector surveillance and control in Hong Kong in 2008 and 2009","volume":"33","author":"Cheung KY","year":"2009","journal-title":"Dengue Bulletin"},{"unstructured":"Centre for Health Protection \u2010 Number of notifiable infectious diseases by month: 2017. 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