{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:36:01Z","timestamp":1758706561859,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T00:00:00Z","timestamp":1527206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502738","81501739","81402542","81471930","81772166","81672015","81660350"],"award-info":[{"award-number":["81502738","81501739","81402542","81471930","81772166","81672015","81660350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Skin disorders vary greatly in symptom and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlation of each HHV infection with different skin disorders remains obscure. To reveal the potential link of a certain type of skin disease with herpesvirus infection, a total of 272 patient tissues with inflammatory or neoplastic skin diseases including 7 subtypes in Shanghai, China, were investigated. We found that the overall prevalence of HHV\u20106A in inflammatory or neoplastic skin tissues is the most common (40.3%), followed by Epstein\u2010Barr virus (17.6%), Kaposi\u2019s sarcoma\u2010associated herpesvirus (KSHV; 9.2%), HHV\u20106B (4.4%), human cytomegalovirus (1.1%), and varicella\u2010zoster virus (0.7%); albeit the co\u2010infection of HHV\u20106A, Epstein\u2010Barr virus, and KSHV presents to a less extent and none of HSV\u20101, HSV\u20102, or HHV\u20107 were detected. Moreover, HHV\u20106A infection is highly associated with nevocytic nevus and seborrheic dermatitis\/keratosis diseases, which mainly occur in the head and the neck or the lower limb. Despite no significant difference among the HHV infections in different age groups of skin patient tissues, the distribution of KSHV infection was exclusively and significantly higher (~3.7\u2010fold) in\u00a0male skin patients.<\/jats:p>","DOI":"10.1002\/jmv.25217","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T20:11:22Z","timestamp":1525464682000},"page":"1532-1540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High prevalence and correlates of human herpesvirus\u20106A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai"],"prefix":"10.1002","volume":"90","author":[{"given":"Ling","family":"Ding","sequence":"first","affiliation":[{"name":"MOE &amp; MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology School of Basic Medical Sciences, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Mo","sequence":"additional","affiliation":[{"name":"MOE &amp; MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology School of Basic Medical Sciences, Fudan University  Shanghai China"},{"name":"Central Laboratory Shanghai Dermatology Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Laboratory Nanchang Hospital of Integrative Traditional Chinese and Western Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"MOE &amp; MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology School of Basic Medical Sciences, Fudan University  Shanghai China"},{"name":"Baoji Health and Family Planning Bureau Baoji Affiliated Hospital of Xi\u2019an Medical University  Baoji Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Zhu","sequence":"additional","affiliation":[{"name":"MOE &amp; MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology School of Basic Medical Sciences, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE &amp; MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology School of Basic Medical Sciences, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cankun","family":"Cai","sequence":"additional","affiliation":[{"name":"MOE &amp; MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology School of Basic Medical Sciences, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pathology Shanghai Dermatology Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wei","sequence":"additional","affiliation":[{"name":"ShengYushou Center of Cell Biology and Immunology School of Life Sciences and Biotechnology, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-0953","authenticated-orcid":false,"given":"Qiliang","family":"Cai","sequence":"additional","affiliation":[{"name":"MOE &amp; MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology School of Basic Medical Sciences, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2005.00189.x"},{"key":"e_1_2_8_1_3_1","first-page":"435","article-title":"Defining skin of color","volume":"69","author":"Taylor SC","year":"2002","journal-title":"Cutis"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit458"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis891"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp013211"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/500509"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050150092023"},{"key":"e_1_2_8_1_9_1","first-page":"1","article-title":"Cbtrus statistical report: primary brain and central nervous system tumors diagnosed in the united states in 2005\u20102009","volume":"15","author":"Dolecek TA","year":"2013","journal-title":"Neuro Oncol"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.7.2384"},{"issue":"3","key":"e_1_2_8_1_12_1","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.DMIH2-0007-2015","article-title":"Human herpesviruses 6a, 6b, and 7","volume":"4","author":"Agut H","year":"2016","journal-title":"Microbiol Spectr"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12208"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.03.086"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2014.09.016"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08382.x"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/723062"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09206.x"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23670"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10083"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(99)00086-4"},{"issue":"1","key":"e_1_2_8_1_22_1","first-page":"S27","article-title":"Differentiated human neural stem cells: a new ex vivo model to study HHV\u20106 infection of the central nervous system","volume":"37","author":"De FL","year":"2006","journal-title":"J Clin Virol"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280591002379"},{"key":"e_1_2_8_1_24_1","first-page":"417","article-title":"Ultrastructural study of human herpesvirus\u20107 replication in tissue culture","volume":"430","author":"Klussmann JP","year":"1997","journal-title":"Archiv F\u00fcr Pathologische Anatomie Und Physiologie Und F\u00fcr Klinische Medicin"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.3.959-963.2001"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.19.10179-10185.2003"},{"key":"e_1_2_8_1_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/592298"},{"key":"e_1_2_8_1_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6104024"},{"key":"e_1_2_8_1_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/421119"},{"key":"e_1_2_8_1_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/423326"},{"key":"e_1_2_8_1_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31802f12ea"},{"key":"e_1_2_8_1_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01525-15"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T21:48:22Z","timestamp":1694987302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,25]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jmv.25217"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25217","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2018,5,25]]},"assertion":[{"value":"2018-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}