{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:59:58Z","timestamp":1793386798382,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministero della Salute, Ricerca Corrente, Rome, Italy","award":["08069614"],"award-info":[{"award-number":["08069614"]}]},{"name":"Fondazione Regionale Ricerca Biomedica, Regione Lombardia, Milan, Italy","award":["2015\/0043"],"award-info":[{"award-number":["2015\/0043"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Immune correlates of protection against human cytomegalovirus (HCMV) infection are still debated. This study aimed to investigate which arm of the immune response plays a major role in protection against HCMV infection in kidney transplant recipients (n\u2009=\u200940) and heart transplant recipients (n\u2009=\u200912). Overall, patients were divided into 2 groups: one including 37 patients with low viral load (LVL), and the other including 15 patients with high viral load (HVL). All LVL patients resolved the infection spontaneously, whereas HVL patients were all treated with one or more courses of antivirals. In HVL patients, viral DNAemia, which was more than 100 times higher than LVL, appeared and peaked at significantly earlier times, but disappeared much later than in LVL patients. During a 1\u2010year follow\u2010up, all LVL patients had levels of HCMV\u2010specific CD4<jats:sup>+<\/jats:sup> (and CD8<jats:sup>+<\/jats:sup>) T cells significantly higher than HVL patients. On the contrary, titers of neutralizing antibodies and enzyme\u2010linked immunosorbent assay\u2010IgG antibodies to gB, gHgLgO, and pentamer gHgLpUL128L were overlapping in the 2 patient groups. In conclusion, while a valid HCMV\u2010specific T\u2010cell response was detected in more than 90% of LVL patients, &gt;90% of HVL patients lacked an adequate T\u2010cell response. Antibody responses did not appear to be associated directly or indirectly with protection.<\/jats:p>","DOI":"10.1002\/jmv.25225","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T07:39:50Z","timestamp":1527147590000},"page":"1620-1628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Human cytomegalovirus (HCMV)\u2010specific T cell but not neutralizing or IgG binding antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid\u2010organ transplant recipients"],"prefix":"10.1002","volume":"90","author":[{"given":"Daniele","family":"Lilleri","sequence":"first","affiliation":[{"name":"Experimental Research Laboratories, Transplantology and Biotechnology Area, Fondazione IRCCS Policlinico San Matteo Pavia 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