{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:33:28Z","timestamp":1791250408282,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004628","name":"MedImmune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory syncytial virus (RSV) is recognized as a serious pathogen in people with chronic cardiopulmonary conditions. Immunoprophylaxis might be considered for adults at high\u2010risk for frequent and severe RSV infection. Thus, we studied the incidence of\u00a0RSV\u2010related medically attended acute respiratory illness (MARI) in adults with severe chronic obstructive pulmonary disease (COPD) and\/or congestive heart failure (CHF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects \u226550 years of age with Gold Class III\/IV COPD and\/or American Heart Association class III\/IV CHF and exposure to children \u2265once per month were recruited. Subjects were evaluated over 1.5 to 2.5 years for RSV\u2010associated MARI, defined as polymerase chain reaction (PCR) and\/or seroresponse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred forty\u2010five subjects were enrolled between October 2011 and May 2012. Overall, 99 RSV infections were documented by PCR or serology for a cumulative incidence of 22.2%. Of these, 42 (9.4%) subjects had protocol\u2010specified RSV\u2010MARI for an incidence of 4.68\/100 patient\u2010seasons. All\u2010cause MARI was common (63.85\/100 patient\u2010seasons) with rhinovirus most commonly identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RSV infection was common in adults with severe COPD and\/or advanced CHF. Given the severity of underlying cardiopulmonary diseases in the study population, most illnesses were surprisingly mild. Thus, active immunization rather than passive immunoprophylaxis with monoclonal antibodies may be a more cost\u2010effective strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25285","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:59:13Z","timestamp":1534953553000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Respiratory syncytial virus\u2013associated illness in adults with advanced chronic obstructive pulmonary disease and\/or congestive heart failure"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-9701","authenticated-orcid":false,"given":"Ann R","family":"Falsey","sequence":"first","affiliation":[{"name":"Department of Medicine, Infectious Diseases Division, University of Rochester Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases Division, University of Rochester Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T","family":"Esser","sequence":"additional","affiliation":[{"name":"MedImmune Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"MedImmune Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[{"name":"MedImmune Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Pam","family":"Griffin","sequence":"additional","affiliation":[{"name":"MedImmune Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"e_1_2_7_1_2_1","first-page":"39","article-title":"Clinical and epidemiologic features of respiratory syncytial virus","volume":"372","author":"Hall CB","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043951"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis309"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.179"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit767"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/380907"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit471"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9911019"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.05.020415"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.165"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix196"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"crossref","unstructured":"The IMpact\u2010RSV Study Group. Palivizumab a humanized respiratory syncytial virus monoclonal antibody reduces hospitalization from respiratory syncytial virus infection in high\u2010risk infants. Pediatrics. 1998;102(3):531\u2010537.","DOI":"10.1542\/peds.102.3.531"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01384-12"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015098"},{"key":"e_1_2_7_1_16_1","unstructured":"Chu M Parhy B Park S et al. Development and pilot study of a dual\u2010target RSV assay to detect and subtype respiratory syncytial virus in nasal swab samples. 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