{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:41:52Z","timestamp":1787953312197,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Recent studies have suggested that human pegivirus 1 (HPgV\u20101) may have some pathogenic potential. In the southernmost region of Brazil, studies on HPgV\u20101 are scarce, and circulating genotypes have not yet been identified. The current study aimed to evaluate the prevalence of HPgV\u20101 among blood donors from the southernmost region of Brazil and identify the genotypes involved with associated factors. A cross\u2010sectional study was conducted with 281 blood donors, who had their plasma subjected to RNA extraction, complementary DNA synthesis, HPgV\u20101 detection by<jats:italic>nested<\/jats:italic>polymerase chain reaction, and subsequent genotyping. The observed prevalence of HPgV\u20101\u2010RNA was 21.7%. The only variable that was significantly associated with virus infection was the relationship status of the donor. Single or no fixed partner blood donors were twice as likely to have HPgV\u20101 (95% CI,\u00a01.12 to 4.56;<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Genotype 2\u2014subtypes 2b (69%) and 2a (29%)\u2014was the most prevalent. In the absence of risk factors for parenteral transmission, it is likely that sexual transmission was the route of infection in the individuals studied. Further work will be needed to determine whether this virus is inert in the population, or if there are\u00a0potential deleterious effects in infected individuals.<\/jats:p>","DOI":"10.1002\/jmv.25291","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T19:51:32Z","timestamp":1534967492000},"page":"31-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High prevalence and autochtonous transmission of human pegivirus (HPgV\u20101) in blood donors in the extreme southern of Brazil"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-1221","authenticated-orcid":false,"given":"Lu\u00edsa D.","family":"Da Mota","sequence":"first","affiliation":[{"name":"Molecular Biology Laboratory School of Medicine, Universidade Federal do Rio Grande Rio Grande 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