{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:54:44Z","timestamp":1782320084238,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["15\u201014\u201000048"],"award-info":[{"award-number":["15\u201014\u201000048"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Tick\u2010borne encephalitis (TBE) remains one of the major public health concerns in northern Eurasia, and its\u2019 area is expanding. TBE virus (TBEV) includes three subtypes and several monophyletic groups, cocirculating in Russia. Five inactivated vaccines are used for TBE prophylaxis. The rising number of people subjected to vaccination brings up the issue of the impact of individual recipient characteristics on vaccination efficacy. The present work studies correlations among the vaccination scheme, sex, age, body mass index (BMI), chronic diseases, postvaccinal reaction, pre\u2010existing anti\u2010TBEV antibodies, and postvaccinal humoral immunity development. Sera were collected during clinical trials in the TBEV Siberian subtype endemic area. Adult recipients were vaccinated with Tick\u2010E\u2010Vac and EnceVir vaccines based on Far\u2010Eastern TBEV strains. Vaccine ability to induce humoral immunity in different categories of recipients was estimated by seroconversion rates and the percentage of recipients with high neutralizing antibody titers (\u22651:500). High immunogenicity of vaccines based on Far\u2010Eastern TBEV strains in the TBEV Siberian subtype endemic area in all groups of recipients was demonstrated. Impact of pre\u2010existing contact with the virus and high BMI on humoral immune response development 14 days after the first\u00a0immunization was evidenced. Nevertheless, the difference was significantly less pronounced 30 days after the first vaccination and undetectable after the second one.<\/jats:p>","DOI":"10.1002\/jmv.25316","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T16:38:13Z","timestamp":1536683893000},"page":"190-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Ability of inactivated vaccines based on far\u2010eastern tick\u2010borne encephalitis virus strains to induce humoral immune response in originally seropositive and seronegative recipients"],"prefix":"10.1002","volume":"91","author":[{"given":"Galina B.","family":"Maikova","sequence":"first","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, FSBSI \u201cChumakov FSC IBP RAS,\u201d Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov L.","family":"Chernokhaeva","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, FSBSI \u201cChumakov FSC IBP RAS,\u201d Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia V.","family":"Rogova","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, FSBSI \u201cChumakov FSC IBP RAS,\u201d Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov I.","family":"Kozlovskaya","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, FSBSI \u201cChumakov FSC IBP RAS,\u201d Moscow Russia"},{"name":"Institute for Translational Medecine and Biotechnology, Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan S.","family":"Kholodilov","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, FSBSI \u201cChumakov FSC IBP RAS,\u201d Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor V.","family":"Romanenko","sequence":"additional","affiliation":[{"name":"Hygienic and Epidemiological Center of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing in Sverdlovsk Region Ekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya S.","family":"Esyunina","sequence":"additional","affiliation":[{"name":"Office of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing in Sverdlovsk Region Ekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Ankudinova","sequence":"additional","affiliation":[{"name":"Ekaterinburg Scientific Research Institute of Virus Infections, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing Ekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S.","family":"Kilyachina","sequence":"additional","affiliation":[{"name":"Ekaterinburg Scientific Research Institute of Virus Infections, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing Ekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail F.","family":"Vorovitch","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, FSBSI \u201cChumakov FSC IBP RAS,\u201d Moscow Russia"},{"name":"Institute for Translational Medecine and Biotechnology, Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-6206","authenticated-orcid":false,"given":"Galina G.","family":"Karganova","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, FSBSI \u201cChumakov FSC IBP RAS,\u201d Moscow Russia"},{"name":"Institute for Translational Medecine and Biotechnology, Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"issue":"1","key":"e_1_2_9_1_2_1","first-page":"6","article-title":"Present distribution area of tick\u2010borne enephalitis in the Russian Federation","volume":"30","author":"Chernokhaeva LL","year":"2016","journal-title":"Med Virol Pro Chumakov IPVE"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.86"},{"key":"e_1_2_9_1_4_1","first-page":"p. 1327","volume-title":"Virus Taxonomy. 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