{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:58:01Z","timestamp":1789577881145,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Bureau of the Chinese Military Commission's logistics support department","award":["16BZJ14"],"award-info":[{"award-number":["16BZJ14"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We assessed the prevalence characteristics of single and multiple high\u2010risk human papillomavirus (HR\u2010HPV) infections. A total of 1783 women who underwent colposcopy and cervical biopsy for abnormal ThinPrep Cytology Test and\/or HR\u2010HPV subtype genotyping results were enrolled in the study. Among the participants, 770 were diagnosed with cervicitis, 395 with cervical intraepithelial neoplasia grade 1 (CIN1), 542 with CIN2\u20103, and 76 with squamous cell carcinoma (SCC), with HR\u2010HPV infection rates of 75.8%, 85.8%, 95.9%, and 88.4%, respectively. The prevalence of total and multiple HR\u2010HPV infections exhibited a bimodal age distribution with a peak at \u226425 years, a decline with age and a second peak at \u226555 years, whereas single HR\u2010HPV infections exhibited one peak from 35 to 44 years. The four most dominant HPV genotypes were HPV 16 (29.5%), 52 (15.0%), 58 (14.2%), and 18 (10.4%). In total, 67.0%, 70.4%, and 82.1% of patients with CIN1, CIN2\u20103, and SCC, respectively, had a single HR\u2010HPV infection, which increased significantly with the aggravation of the cervical lesion grade (<jats:italic>P<\/jats:italic>\u2009=\u20090.045). Patients with a single HPV 16 infection had higher incidences of CIN2+ (62.2%) than those with multiple HPV 16 infections (52.4%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.021). Patients coinfected with HPV 16 had higher CIN2+ incidence than those with single HPV 52, 31, 33, 35, 39, 45, 51, 56, or 59 infections (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). This study provided baseline data on the prevalence characteristics of single and multiple HR\u2010HPV infections in women attending a gynecological outpatient clinic in Beijing.<\/jats:p>","DOI":"10.1002\/jmv.25331","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T15:43:16Z","timestamp":1538754196000},"page":"473-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Prevalence characteristics of single and multiple HPV infections in women with cervical cancer and precancerous lesions in Beijing, China"],"prefix":"10.1002","volume":"91","author":[{"given":"Mingxia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital Beijing 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