{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:43:49Z","timestamp":1780393429764,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Young and Middle-aged High-level Medical Reserved Talents Training Project, Chongqing Municipal Health and Family Planning Commission, China","award":["2018GDRC002"],"award-info":[{"award-number":["2018GDRC002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>To investigate the serum anti\u2010hepatitis E virus (HEV) antibody positive rate in patients with different types of chronic hepatitis (CH) or cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1751 hospitalized patients were chart reviewed, who were diagnosed with mono\u2010CH or cirrhosis between 2011 and 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total anti\u2010HEV\u2010IgG positive rate was 1.33% (13\/981) in CH patients, which was significantly lower than that (6.49%; 50\/770) in cirrhosis patients (odds ratio [OR], 4.78 [2.51\u20109.10]; <jats:italic>P<\/jats:italic>\u2009=\u20090.00). The comparison of positive rate of anti\u2010HEV\u2010IgG between the same etiology CH and cirrhosis groups was as follows: chronic hepatitis B 1.27% (10\/790) versus hepatitis B virus (HBV)\u2010related cirrhosis 4.21% (22\/522) (OR, 3.04 [1.36\u20106.77]; <jats:italic>P<\/jats:italic>\u2009=\u20090.00); chronic alcoholic hepatitis 1.41% (1\/71) versus alcoholic cirrhosis 9.40% (11\/117) (OR, 8.00 [1.00\u201064.25]; <jats:italic>P<\/jats:italic>\u2009=\u20090.03); chronic autoimmune hepatitis 1.69% (1\/59) versus autoimmune cirrhosis 13.33% (12\/90) (OR, 13.11 [1.49\u2010115.27]; <jats:italic>P<\/jats:italic>\u2009=\u20090.01); the differences above were statistically significant. And chronic hepatitis C 3.23% (1\/31) versus hepatitis C virus\u2010related cirrhosis 10.81% (4\/37) (OR, 4.40 [0.45\u201043.53]; <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05); chronic NASH 0.00% (0\/30) versus NASH\u2010related cirrhosis 25.00% (1\/4) (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), the differences were not statistically significant. Anti\u2010HEV\u2010IgG positive rates were also compared among different types of CH groups and no significant difference was found. Likewise, anti\u2010HEV\u2010IgG positive rate was compared among different types of cirrhosis groups, showing that the positive rates of both alcoholic cirrhosis (9.40%) and autoimmune cirrhosis (13.33%) were significantly higher than that of HBV\u2010related cirrhosis (4.21%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed that the cirrhosis patients had a significantly higher anti\u2010HEV\u2010IgG positive rate comparing with the CH patients, especially in those with HBV\u2010related, alcohol\u2010related, and autoimmune\u2010related cirrhosis (after adjusted for age). Additionally, it seems that the conditions of alcoholic cirrhosis and autoimmune cirrhosis are more susceptible to HEV infection due to the significantly higher positive anti\u2010HEV\u2010IgG rate in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25335","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T15:36:51Z","timestamp":1539272211000},"page":"437-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retrospectively seroprevalence study on anti\u2010HEV\u2010IgG antibody in patients with chronic hepatitis or liver cirrhosis in a Chinese teaching hospital"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-6832","authenticated-orcid":false,"given":"Hongying","family":"Yang","sequence":"first","affiliation":[{"name":"Respiratory Department of Chengdu Sixth People's Hospital Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Wu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of People's Hospital of Fengjie Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Intensive Care Department of Chongqing Ninth People's Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Infectious and Parasitic Diseases in Chongqing, Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Infectious and Parasitic Diseases in Chongqing, Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"e_1_2_6_1_2_1","first-page":"5","volume-title":"Acute and Chronic Liver Diseases: Molecular Biology and Clinics","author":"Schmid R","year":"1996"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444468"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12405"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.384"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-6-334"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708687"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit224"},{"issue":"6","key":"e_1_2_6_1_9_1","first-page":"314","article-title":"Seroprevalence of hepatitis E virus in patients with hepatitis C and \/ or infected with HIV","volume":"28","author":"L\u00f3pez\u2010Fabal MF","year":"2015","journal-title":"Rev Esp Quimioter"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02343-15"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.251.hpe"},{"issue":"1","key":"e_1_2_6_1_12_1","first-page":"143","article-title":"HEV infection in patients with PHC or hepatocirrhosis","volume":"34","author":"Mianchu Liao","year":"1995","journal-title":"J Xiamen Univ (Nat Sc)"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.01.005"},{"key":"e_1_2_6_1_14_1","unstructured":"F. 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